NLCR in Prediction of the Grade of Lung Tumor.

Lung Neoplasm Clinical Trial

Official title:

Preoperative Neutrophil-lymphocyte Count Ratio in Prediction of the Grade of Lung Tumor.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03749512
• Other study ID #: NLCR-01
• Status: Completed
• Start date: October 1, 2014
• Est. completion date: November 16, 2018

Study information

• Verified date: November 2018
• Source: Medical University of Silesia
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading.

Description:

Lung cancer remains as one of the leading causes of death among oncology patients. Close connection between inflammation and pathogenesis of some neoplasms was determined in a number of studies. Some studies show promise that ratio of neutrophil to lymphocyte count (NLCR) may be recognized as a prognostic marker for several carcinomas: renal, lung and colorectal. The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading. During routine preoperative blood tests complete blood count is done and NLCR, WBC, neutrophil and lymphocyte count is noted. After the thoracic surgery intervention and histopathological examination grading of lung tumor is noted.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 400
• Est. completion date: November 16, 2018
• Est. primary completion date: October 15, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• consecutive thoracic surgery patients with lung cancer grading confirmed by histopathology postoperatively

• preoperative routine complete blood count analysis

Exclusion Criteria:

• infectious disease

• pregnancy

• autoimmunologic disease

• other known conditions or treatments that may influence the blood count (seropositivity for HIV, chemotherapy, and corticotherapy)

Related Conditions & MeSH terms

• Lung Neoplasm
• Lung Neoplasms

Intervention

Diagnostic Test:
• Complete blood count
During routine preoperative blood test complete blood count is taken.

Other:
• Histopathological examination
Routine postoperative histopathological examination of lung tumor.

Locations

Country	Name	City	State
Poland	Samodzielny Publiczny Szpital Kliniczny nr 1	Zabrze	Silesia

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Silesia

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neutrophil-lymphocyte count ratio	Neutrophil-lymphocyte count ratio is measured during routine preoperative blood tests.	From October 1, 2014 to October 15, 2018
Secondary	Neutrophil count	Neutrophil count is measured during routine preoperative blood tests.	From October 1, 2014 to October 15, 2018
Secondary	Lymphocyte count	Lymphocyte count is measured during routine preoperative blood tests.	From October 1, 2014 to October 15, 2018
Secondary	Leucocyte count	Leucocyte count is measured during routine preoperative blood tests.	From October 1, 2014 to October 15, 2018