Feasibility Study of Anatomical Modeling for Image Guided Thoracic Surgery

Status Recruiting

Clinical Trial Summary

This clinical trial assesses the feasibility of creating a 3 dimensional (D) model of the lung and lung nodule(s) from computed tomography (CT) scan images performed during lung surgery. Unlike solid organs (like the kidney, brain, and liver), the lung changes shape (they inflate when a person breathe in and collapse when they breathe out). This makes it difficult to predict where, exactly, the tumor(s) will be on the lungs during surgery. A 3D model may help surgeons better predict where the location of the tumor(s) will be during surgery.

Clinical Trial Description

PRIMARY OBJECTIVE: I. To assess the feasibility of developing an anatomical model to predict the location of the tumor in a deflated lung to assist in guidance during lung surgery. SECONDARY OBJECTIVES: I. Develop a registration technique to register the tumor onto the 2D/3D optical image obtained during surgery. II. Determine the accuracy of mapping major segmental vasculature and bronchial structures onto 2D/3D optical images obtained during surgery. OUTLINE: Patients undergo 4 CT scans during standard of care surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05046067
Study type	Interventional
Source	M.D. Anderson Cancer Center
Contact
Status	Recruiting
Phase	N/A
Start date	September 16, 2020
Completion date	April 30, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05078918` - Comprehensive Care Program for Their Return to Normal Life Among Lung Cancer Survivors	N/A
Completed	`NCT04508270` - Significance of Early Mobilization After VATS-L
Active, not recruiting	`NCT03667716` - COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.	Phase 1
Completed	`NCT05469425` - Home-based Preoperative Exercise Training for Lung Cancer Patients Undergoing Surgery	N/A
Terminated	`NCT03090880` - Prophylaxis of Venous Thromboembolism in Advanced Lung Cancer (PROVE)	Phase 3
Recruiting	`NCT05596760` - Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers	N/A
Completed	`NCT02498860` - Efficacy and Safety of Adjuvant Pemetrexed Plus Cisplatin for Adenocarcinoma of Lung	Phase 2
Completed	`NCT02952261` - Application of 3D Printing Technique in Small Pulmonary Nodule Localization	N/A
Not yet recruiting	`NCT06024538` - Role of Cancer-associated Fibroblast, MDSCs and Immune Cell Interplays in the Resistance of Non-small Cell Lung Cancer to Anti-PD1/PD-L1 Therapies
Recruiting	`NCT02965300` - The Value of VOCs Analysis in Exhaled Breath for Pulmonary Benign and Malignant Lesion Diagnosis	N/A
Completed	`NCT02616211` - An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors
Recruiting	`NCT00765986` - Pilot Study of 18F-FAZA in Assessing Early Functional Response in Patients With Inoperable Non Small Cell Lung Cancer Undergoing Radiotherapy or Chemo-radiotherapy	N/A
Completed	`NCT03320044` - Early Diagnosis of Small Pulmonary Nodules by Multi-omics Sequencing
Recruiting	`NCT03655015` - Patient-derived Organoid Model and Circulating Tumor Cells for Treatment Response of Lung Cancer
Completed	`NCT03741868` - Symptom Burden and Unmet Supportive Care Needs in Lung Cancer Patients Undergoing First or Second Line Immunotherapy
Completed	`NCT03749512` - NLCR in Prediction of the Grade of Lung Tumor.
Recruiting	`NCT03664843` - Circulating Tumor DNA Longitudinal Monitoring in Stage III-IV Lung Cancer Patients
Completed	`NCT01261507` - Reader Study of DeltaView™ Chest Radiograph Software	N/A
Terminated	`NCT01064050` - Role of a Silicone Prosthesis to Prevent Airway Obstruction Recurrence in Lung Cancers	Phase 4
Recruiting	`NCT03765775` - Anlotinib Plus Sintilimab for NSCLC Patients With First-generation EGFR-TKIs Drug Resistance Along With T790M Negative	Phase 2