Hypofractionated Radiotherapy for Limited Stage Small Cell Lung Cancer

Status Completed

Clinical Trial Summary

It is accepted that giving higher doses of chest radiation in as short a time span as possible improves chances of cure. In this study, the investigators propose to give an increased dose of chest radiotherapy for limited stage small cell lung cancer patients using a strategy of giving a slightly higher daily dose of radiotherapy than normal. The investigators hypothesize that our proposed chest radiotherapy dose will improve 2-year overall survival rates in patients with limited stage small cell lung cancer.

Clinical Trial Description

The ideal chest radiotherapy dose/fractionation scheme for limited stage small cell lung cancer is undefined. Strategies of radiotherapy dose intensification with minimization of overall treatment time are felt to improve cure rates for LS-SCLC. Hypofractionation (giving higher than standard daily doses) facilitates both of these goals. In this study, we propose to use a dose escalated hypofractionated regimen of chest radiotherapy for patients with LS-SCLC. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00907569
Study type	Interventional
Source	AHS Cancer Control Alberta
Contact
Status	Completed
Phase	Phase 2
Start date	June 2009
Completion date	April 2011

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05078918` - Comprehensive Care Program for Their Return to Normal Life Among Lung Cancer Survivors	N/A
Completed	`NCT04508270` - Significance of Early Mobilization After VATS-L
Active, not recruiting	`NCT03667716` - COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.	Phase 1
Completed	`NCT05469425` - Home-based Preoperative Exercise Training for Lung Cancer Patients Undergoing Surgery	N/A
Recruiting	`NCT05046067` - Feasibility Study of Anatomical Modeling for Image Guided Thoracic Surgery	N/A
Terminated	`NCT03090880` - Prophylaxis of Venous Thromboembolism in Advanced Lung Cancer (PROVE)	Phase 3
Recruiting	`NCT05596760` - Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers	N/A
Completed	`NCT02498860` - Efficacy and Safety of Adjuvant Pemetrexed Plus Cisplatin for Adenocarcinoma of Lung	Phase 2
Completed	`NCT02952261` - Application of 3D Printing Technique in Small Pulmonary Nodule Localization	N/A
Not yet recruiting	`NCT06024538` - Role of Cancer-associated Fibroblast, MDSCs and Immune Cell Interplays in the Resistance of Non-small Cell Lung Cancer to Anti-PD1/PD-L1 Therapies
Recruiting	`NCT02965300` - The Value of VOCs Analysis in Exhaled Breath for Pulmonary Benign and Malignant Lesion Diagnosis	N/A
Completed	`NCT02616211` - An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors
Recruiting	`NCT00765986` - Pilot Study of 18F-FAZA in Assessing Early Functional Response in Patients With Inoperable Non Small Cell Lung Cancer Undergoing Radiotherapy or Chemo-radiotherapy	N/A
Completed	`NCT03320044` - Early Diagnosis of Small Pulmonary Nodules by Multi-omics Sequencing
Recruiting	`NCT03655015` - Patient-derived Organoid Model and Circulating Tumor Cells for Treatment Response of Lung Cancer
Completed	`NCT03741868` - Symptom Burden and Unmet Supportive Care Needs in Lung Cancer Patients Undergoing First or Second Line Immunotherapy
Not yet recruiting	`NCT05179408` - Telerehabilitation Following Lung Cancer	N/A
Completed	`NCT03749512` - NLCR in Prediction of the Grade of Lung Tumor.
Recruiting	`NCT03664843` - Circulating Tumor DNA Longitudinal Monitoring in Stage III-IV Lung Cancer Patients
Completed	`NCT01261507` - Reader Study of DeltaView™ Chest Radiograph Software	N/A