Mechanical Ventilation Complication Clinical Trial
Official title:
The Effects of Airway Closure, Expiratory Flow Limitation and of a Passive Chest Wall on the Onset of an Uncontrolled Expiration and on Intracranial Pressure. An Observational Clinical Study on Neurosurgical Patients. (The CeRes-CMV Study)
The impact of mechanical ventilation on intracranial perfusion is still not completely clarified. It is often assumed that raising airway pressure will invariably elevate the intracranial pressure, but this is not always the case. The effects of airway pressure on intracranial pressure can depend on several factors, and among others, an uncontrolled expiration and consequent lung collapse may have an influence on cerebral perfusion. This study will investigate the incidence and the consequences of an uncontrolled expiration and expiratory lung collapse in critically ill neurosurgical patients during controlled mechanical ventilation. Electrical impedance tomography measurements , oesophagus and gastric pressure, electrical activity of the diaphragm and intracranial pressure will be acquired in a synchronised manner during controlled mechanical ventilation. Moreover, airway opening pressure, expiratory flow limitation and recruitment/inflation ratio will be determined during controlled mechanical ventilation, on a daily bases until the patient recover his/her own spontaneous breathing.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05030337 -
Optimising Ventilation in Preterms With Closed-loop Oxygen Control
|
N/A | |
| Completed |
NCT05144607 -
Impact of Inspiratory Muscle Pressure Curves on the Ability of Professionals to Identify Patient-ventilator Asynchronies
|
N/A | |
| Recruiting |
NCT03697785 -
Weaning Algorithm for Mechanical VEntilation
|
N/A | |
| Completed |
NCT05084976 -
Parental Perception of COVID-19 Vaccine in Technology Dependent Patients
|
||
| Active, not recruiting |
NCT05886387 -
a Bayesian Analysis of Three Randomised Clinical Trials of Intraoperative Ventilation
|
||
| Completed |
NCT04429399 -
Lowering PEEP: Weaning From High PEEP Setting
|
N/A | |
| Completed |
NCT02249039 -
Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study
|
Phase 1 | |
| Recruiting |
NCT02071524 -
Evaluation of the Effects of Fluid Therapy on Respiratory Mechanics
|
N/A | |
| Completed |
NCT01114022 -
Prevention Inhalation of Bacterial by Using Endotracheal Tube Balloon Polyvinyl Chloride or Polyurethane
|
N/A | |
| Completed |
NCT00893763 -
Strategies To Prevent Pneumonia 2 (SToPP2)
|
Phase 2 | |
| Terminated |
NCT05056103 -
Automated Secretion Removal in ICU Patients
|
N/A | |
| Active, not recruiting |
NCT04558476 -
Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation
|
Phase 2 | |
| Recruiting |
NCT05295186 -
PAV Trial During SBT Trial
|
||
| Active, not recruiting |
NCT05370248 -
The Effect of 6 ml/kg vs 10 ml/kg Tidal Volume on Diaphragm Dysfunction in Critically Mechanically Ventilated Patient
|
N/A | |
| Completed |
NCT04818164 -
Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Acute Respiratory Distress Syndrome
|
||
| Completed |
NCT04589910 -
Measuring Thickness of the Normal Diaphragm in Children Via Ultrasound.
|
N/A | |
| Completed |
NCT04193254 -
LPP , MP and DP:Relation With Mortality and SOFA in Mechanically Ventilated Patients in ER, Ward and ICU
|
||
| Not yet recruiting |
NCT03245684 -
Assisted or Controlled Ventilation in Ards (Ascovent)
|
N/A | |
| Not yet recruiting |
NCT03259854 -
Non Invasive Mechanical Ventilation VERSUS Oxygen MASK
|
N/A | |
| Completed |
NCT06332768 -
NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients
|
N/A |