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Clinical Trial Summary

The impact of mechanical ventilation on intracranial perfusion is still not completely clarified. It is often assumed that raising airway pressure will invariably elevate the intracranial pressure, but this is not always the case. The effects of airway pressure on intracranial pressure can depend on several factors, and among others, an uncontrolled expiration and consequent lung collapse may have an influence on cerebral perfusion. This study will investigate the incidence and the consequences of an uncontrolled expiration and expiratory lung collapse in critically ill neurosurgical patients during controlled mechanical ventilation. Electrical impedance tomography measurements , oesophagus and gastric pressure, electrical activity of the diaphragm and intracranial pressure will be acquired in a synchronised manner during controlled mechanical ventilation. Moreover, airway opening pressure, expiratory flow limitation and recruitment/inflation ratio will be determined during controlled mechanical ventilation, on a daily bases until the patient recover his/her own spontaneous breathing.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05363085
Study type Observational
Source Uppsala University
Contact Mariangela Pellegrini, MD, PhD
Phone +460186110000
Email mariangela.pellegrini@surgsci.uu.se
Status Not yet recruiting
Phase
Start date May 2022
Completion date May 2023

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