Clinical Trials Logo

Clinical Trial Summary

Collect exhaled breath condensates from patients scheduled for a routine surgical procedure before, during, and after surgery for measurements of IsoFs

Draw blood from patients scheduled for a routine surgical procedure before, during, and after surgery for measurements of serum thrombomodulin.


Clinical Trial Description

High concentrations of oxygen are routinely administered to patients undergoing routine surgical procedures even though it is highly likely, at least in patients with normal lung function, that this is unnecessary and in fact may be doing unnecessary harm. Therefore, we plan to assess whether there is any evidence of lung injury during surgery resulted from administration of high concentrations of oxygen by measuring Isofurans (IsoFs) in exhaled breath condensate. In our studies in mice that were exposed to high concentrations of oxygen we also found that circulating levels of thrombomodulin were increased. Thrombomodulin is present in endothelial cells and upon injury they release thrombomodulin into the circulation. Endothelial cell injury is known to occur in hyperoxic-induced lung injury. Therefore, in addition to measuring IsoFs in exhaled breath condensate we will also measure plasma concentrations of thrombomodulin as an indicator of endothelial injury. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00715338
Study type Observational
Source Vanderbilt University Medical Center
Contact
Status Terminated
Phase N/A
Start date June 2008
Completion date September 2008

See also
  Status Clinical Trial Phase
Completed NCT00498251 - Prevention of Lung Edema After Thoracic Surgery N/A
Completed NCT01597635 - The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury Phase 2
Completed NCT00141726 - Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant Phase 2
Completed NCT00996840 - SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS Phase 2
Completed NCT03651817 - Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg N/A
Recruiting NCT05680831 - Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air Phase 1
Completed NCT03764319 - Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO N/A
Completed NCT01640990 - A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an Intravenous Infusion of GW328267X in Healthy Volunteers Phase 1
Completed NCT01114009 - Effects of Recruitment Maneuvers in Early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) Patients N/A
Recruiting NCT03202641 - Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients N/A
Completed NCT03828630 - Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients
Completed NCT03905837 - Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery Phase 4
Completed NCT03023670 - Lung Protection and Pediatric Cardiac Surgery N/A
Recruiting NCT05647967 - Features of Regional Perfusion of Lung Consolidation
Recruiting NCT04289324 - Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants N/A
Completed NCT05647382 - Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass N/A
Completed NCT05610475 - Serum Level of Calpains Product as a Novel Biomarker of Acute Lung Injury Following Cardiopulmonary Bypass N/A
Recruiting NCT04511923 - Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury Phase 1/Phase 2
Active, not recruiting NCT03637530 - a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries N/A
Completed NCT04344184 - SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI) Phase 2