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Lung Injury, Acute clinical trials

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NCT ID: NCT05680831 Recruiting - Symptoms and Signs Clinical Trials

Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air

LOCONOZ2
Start date: October 13, 2022
Phase: Phase 1
Study type: Interventional

Purpose: The primary purpose of this study is to measure pulmonary function, symptoms, and pulmonary inflammatory responses in healthy young adults during and immediately after exposure to a low concentration of ozone (0.070 ppm) or clean air for 6.6 hours while undergoing moderate intermittent exercise. This concentration is the current EPA NAAQS standard for ozone.

NCT ID: NCT05647967 Recruiting - Clinical trials for Ultrasound Therapy; Complications

Features of Regional Perfusion of Lung Consolidation

Start date: January 1, 2022
Phase:
Study type: Observational

The aim of this study is to evaluate the potential usefulness of lung ultrasound to assess the size and perfusion of consolidation and explore their relationships with clinical outcome.

NCT ID: NCT05647382 Completed - ARDS Clinical Trials

Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass. However, the incidence of postoperative acute lung injury due to cardiopulmonary bypass is still as high as 20% to 35%. According to clinical experience, the earlier lung damage is detected, the more successful the treatment will be. On the basis of traditional detection, the investigators found a new indicator, serum soluble vascular endothelial-cadherin, which are easy to obtain and have certain specificity. Importantly, they can predict postoperative acute lung injury within 1 hour after cardiac surgery. It is meaningful that this indicator can provide clinicians with early decision-making advice and immediate treatment for patients who may be at risk.

NCT ID: NCT05610475 Completed - Lung Injury, Acute Clinical Trials

Serum Level of Calpains Product as a Novel Biomarker of Acute Lung Injury Following Cardiopulmonary Bypass

CPB
Start date: February 1, 2022
Phase: N/A
Study type: Interventional

More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass. However, the incidence of postoperative acute lung injury due to cardiopulmonary bypass is still as high as 20% to 35%. According to clinical experience, the earlier lung damage is detected, the more successful the treatment will be. On the basis of traditional detection, the investigators found a new indicator, serum calpains, which are easy to obtain and have certain specificity. Importantly, they can predict postoperative acute lung injury within 1 hour after cardiac surgery. It is meaningful that this indicator can provide clinicians with early decision-making advice and immediate treatment for patients who may be at risk.

NCT ID: NCT04511923 Recruiting - Covid19 Clinical Trials

Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury

CHARTER-Irl
Start date: December 23, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

The investigators present a randomised open label phase Ib/IIa trial of nebulised unfractionated heparin to evaluate the effect of nebulised unfractionated heparin on the procoagulant response in ICU patients with SARS-CoV-2 requiring advanced respiratory support. As this is one of the first studies of nebulised heparin in COVID 19 lung disease the investigators will assess safety as a co-primary outcome.

NCT ID: NCT04499378 Recruiting - Covid19 Clinical Trials

Tomographic Findings in COVID-19 and Influenza H1N1

Start date: August 15, 2020
Phase:
Study type: Observational

The investigators decided to conduct a longitudinal study that compares the pulmonary tomographic patterns found in patients with viral pneumonia (i.e. influenza H1N1 and SARS-CoV-2) at a regional hospital. The primary aim of this study is to evaluate the association between the radiological CT pattern and the need for invasive mechanical ventilation. A secondary aim is to assess the mortality within the first 28 days of intensive care unit admission.

NCT ID: NCT04344184 Completed - COVID-19 Clinical Trials

SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)

Start date: December 18, 2020
Phase: Phase 2
Study type: Interventional

This study will evaluate the safety of a 96-hour intravenous vitamin C infusion protocol (50 mg/kg every 6 hours) in patients with hypoxemia and suspected COVID-19.

NCT ID: NCT04289324 Recruiting - Extreme Prematurity Clinical Trials

Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants

OPEN4HFOV
Start date: February 25, 2020
Phase: N/A
Study type: Interventional

To assess whether stepwise oxygenation-guided lung recruitment at regular intervals reduces the oxygen saturation index (OSI = Mean Airway Pressure × Fraction of inspired Oxygen × 100 / peripheral Oxygen Saturation, OSI = MAPxFiO2x100/SpO2) averaged over high frequency oscillation ventilation (HFOV) time in extremely preterm infants.

NCT ID: NCT03905837 Completed - Clinical trials for Postoperative Complications

Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery

Start date: January 28, 2019
Phase: Phase 4
Study type: Interventional

The purpose of this study is to analyze the impact of the intravenous (IV) or paravertebral (PV) lidocaine administration during the intraoperative period of lung resection surgery on the appearance of postoperative complications. We design a randomized, controlled and blinded study to be performed in 153 patients with 3 arms: 1) Lidocaine IV + PV saline 2) saline IV + PV lidocaine, 3) remifentanil IV + PV saline. Perioperative analysis of inflammatory biomarkers in bronchoalveolar lavage and serum. Follow-up of the postoperative course, especially the appearance of postoperative complications according to the revised Clavien-Dindo classification for thoracic surgery, as well as other relevant clinical results.

NCT ID: NCT03828630 Completed - Clinical trials for Acute Respiratory Distress Syndrome

Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients

LUSIP
Start date: July 8, 2018
Phase:
Study type: Observational

This study aims at describing the frequency, timing and type of pulmonary complications detected with lung ultrasound in critically-ill parturients in admitted to a high-dependency unit in Freetown, Sierra Leone.