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Clinical Trial Summary

Cough is the most unwanted response during bronchoscopic interventions for hemodynamic instability, hypoxemia, and interruption of interventions. In previous reports, there were many drugs and techniques investigated for preventing cough during broncoscopic examinations. As bronchoscopic interventions need more space and stability of airways to precisely operate on, few studies have focused on the effects of different drugs for preventing cough. In this study, Different intravenous drugs (lidocaine, etomidate, compared to normal saline) is planned to be injected one minutes before bronchoscopic insertion, the responses to bronchoscopicly spraying local anesthetic were recorded and analyzed.


Clinical Trial Description

Cough is the most unwanted response during bronchoscopic interventions. Cough could lead to airway spasm, hemodynamic instability, desaturation, hypoventilation, and then interrupt the following interventions. In previous reports, lodicaine and other drugs given intravenously, inhalationally or trans-cricoidally have been investigated for preventing cough during conventional broncoscopic examinations. As bronchoscopic interventions were goaled to precise localization and operations with higher yield rate. Steady airways without endotracheal tubes are usually required. There are few studies focused on the effects of different drugs for preventing cough even bronchoscopic spary of local anesthetics has become the routine pratise before interventions. In this study, different intravenous drugs (lidocaine, etomidate, compared to normal saline) are planned to be injected one minutes before bronchoscopic insertion, the responses to bronchoscopicly spraying local anesthetic were recorded and analyzed. Besdies cough scores, the following changes are recorded and compared: (1) status on visualization and the responses to sparying of vocal cords, (2) anesthetic depth (BIS levels), (3) blood pressure and heart beats, (4) data of hemoglobin saturation (SPO2) and Transdermal CO2. We goaled to compare the effects of intravenous lidocaine and etomidate on cough intensity, hemodynamics, ventilation, and bronchoscopic withdrawl rate during bronchoscopic interventions with intravenous anethesia. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05072236
Study type Interventional
Source National Taiwan University Hospital
Contact cheng yajung
Phone 0930050762
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date October 1, 2021
Completion date October 31, 2022

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