Predictive Factors, Demographics and Mortality for ARDS in Burn Patients

Lung Diseases Clinical Trial

Official title:

Predictive Factors, Demographics and Mortality for ARDS in Burn Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03807232
• Other study ID #: ARDS in Burn Patients USZ
• Status: Completed
• Start date: August 26, 2010
• Est. completion date: May 23, 2013

Study information

• Verified date: January 2019
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This retrospective study characterizes the clinical course and identifies four independent predictors of Acute Respiratory Distress Syndrome (ARDS) after burn injury (post-burn ARDS; pbARDS). In addition, a clinically useful prognostic score for pbARDS is introduced (ARDS burn score), which was derived from these independent predictors. The newly developed score may be helpful for the development of specific treatment strategies.

Description:

Rationale:

Acute Respiratory Distress Syndrome (ARDS) after burn injury (post-burn ARDS; pbARDS) is a severe complication associated with a mortality of up to 44%. To date, only few studies have been published on the clinical course and predictive factors of pbARDS.

Objectives:

To characterize the clinical course of pbARDS, to identify relevant predictors, including the development of a prognostic score, and to examine outcome parameters such as mortality and hospitalization days.

Methods:

A retrospective analysis of 400 patients admitted to the Burns Intensive Care Unit of the University Hospital Zurich from 2004 to 2009 was performed. Multivariate logistic regression was used to determine independent risk factors for pbARDS. A prognostic score was developed, which was tested with leave-one-out-cross-validation and Receiver Operating Characteristic (ROC) curves.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 400
• Est. completion date: May 23, 2013
• Est. primary completion date: May 23, 2013
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years and older

Eligibility

Inclusion Criteria:

all patients treated at the Burns Intensive Care Unit (BICU) of the University Hospital Zurich (USZ) between January 2004 and December 2009.

Exclusion Criteria:

Exclusions were made because of incomplete or unavailable data, re-hospitalization due to complications of previous burns, and the initial decision not to resuscitate due to unfavorable prognosis.

Related Conditions & MeSH terms

• ARDS, Human
• Burns
• Lung Diseases
• Respiratory Distress Syndrome, Adult

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of post-burn ARDS	Number of patients who developed post-burn ARDS among 400 Patients admitted to Burns Intensive Care Unit of University Hospital Zurich	6 years
Primary	Clinical course of post-burn-ARDS	various clinical parameters related to the Outcome of post-burn-ARDS	6 years
Primary	predictors of post-burn ARDS	To identify relevant predictors of post-burn ARDS, including the development of a prognostic score	6 years
Secondary	to examine outcome parameter mortality	A retrospective analysis of 400 patients admitted to the Burns Intensive Care Unit of the University Hospital Zurich	6 years
Secondary	to examine outcome parameter hospital stay	A retrospective analysis of 400 patients admitted to the Burns Intensive Care Unit of the University Hospital Zurich	6 years