Idiopathic Pulmonary Fibrosis: a Case-control Study

Lung Diseases Clinical Trial

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00005295
• Other study ID #: 2018
• Secondary ID: R01HL043153
• Status: Terminated
• Start date: July 1989
• Est. completion date: June 1995

Study information

• Verified date: March 2024
• Source: University of New Mexico
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To determine risk factors for idiopathic pulmonary fibrosis.

Description:

BACKGROUND:

Idiopathic pulmonary fibrosis is a progressive and generally fatal disease that causes fibrosis of the pulmonary interstitium. While many environmental agents cause diseases clinically similar, the etiology of idiopathic pulmonary fibrosis suggests that environmental agents could incite the tissue injury that results in the disease; furthermore, host characteristics could have an important role in determining the magnitude of the host response to the agent initiating injury.

DESIGN NARRATIVE:

In this case control study, cases were ascertained at the multiple collaborating centers and controls were identified by telephone screening. A telephone interview was conducted to collect information needed to test hypotheses concerning cigarette smoking, occupational exposure, indoor exposures, other environmental factors, and host factors. To limit disease misclassification, two pathologists experienced with interstitial diseases of the lung reviewed histopathological material from all cases to exclude entities other than interstitial lung fibrosis and to fully characterize the cases clinically. The mortality of this large series of cases was also described.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 0
• Est. completion date: June 1995
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 0 Years to 100 Years
• Eligibility: No eligibility criteria

Related Conditions & MeSH terms

• Fibrosis
• Lung Diseases
• Lung Diseases, Interstitial
• Pulmonary Fibrosis

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
University of New Mexico	National Heart, Lung, and Blood Institute (NHLBI)

References & Publications (2)

Baumgartner KB, Samet JM, Stidley CA, Colby TV, Waldron JA. Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1997 Jan;155(1):242-8. doi: 10.1164/ajrccm.155.1.9001319. — View Citation

Coultas DB, Gong H Jr, Grad R, Handler A, McCurdy SA, Player R, Rhoades ER, Samet JM, Thomas A, Westley M. Respiratory diseases in minorities of the United States. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 2):S93-131. doi: 10.1164/ajrccm/149.3_Pt_2.S93. No abstract available. Erratum In: Am J Respir Crit Care Med 1994 Jul;150(1):290. — View Citation