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Lung Diseases, Interstitial clinical trials

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NCT ID: NCT04136223 Active, not recruiting - Clinical trials for Rheumatoid Arthritis

Rheumatoid Arthritis-Associated Interstitial Lung Disease: Characterization of Lung Disease Progression

BERTHA
Start date: March 1, 2021
Phase:
Study type: Observational

BERTHA study´s primary objective is to characterize Rheumatoid Arthritis-associated Interstitial Lung Disease (RA-ILD) progression and to define a combination of biomarkers, genetic and clinical variables capable of identifying patients at risk of RA-ILD progression

NCT ID: NCT04100226 Active, not recruiting - Clinical trials for Vitamin D Deficiency

Vitamin D Deficiency and Effect of Its Supplementation on Interstitial Lung Diseases(ILD).

ILD
Start date: March 1, 2019
Phase: N/A
Study type: Interventional

This study evaluates serum level of Vitamin D in Interstitial Lung Diseases in patients with Interstitial Lung Diseases other than connective tissue diseases associated-Interstitial Lung Diseases and effects of its supplementation. All patients will receive the standard regimen of treatment (corticosteroids and immunosuppressive drugs)and will be randomly assigned to either Group 1:who will receive Vitamin D supplementation (Interventional group)or Group 2:who will not receive Vitamin D supplementation(Control group).

NCT ID: NCT03995654 Active, not recruiting - Clinical trials for Lung Diseases, Interstitial

Research of Burden of Interstititial Lung Diseases in Turkey

RBILD
Start date: January 1, 2019
Phase:
Study type: Observational [Patient Registry]

The aim of our study is to investigate the etiological distribution of ILD, epidemiological characteristics of ILD cases such as age, gender, geography, smoking, occupation, economic status, education, and comorbidities. Another aim is to make the cost calculation from the first to the diagnosis in the patients diagnosed. Obtaining the missing data related to the ILD of our country is one of our goals.

NCT ID: NCT03869515 Active, not recruiting - Genetic Testing Clinical Trials

Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China

Start date: March 25, 2019
Phase:
Study type: Observational

Recruitment of a carefully characterized cohort of chILD patients, to generate a database and biobank via collecting data on chILD in China. Importantly, compatibility with ongoing United States and Europe chILD data base developments will be factored in.

NCT ID: NCT03747627 Active, not recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

BPF Genetics of ILD Study

BPF GILD
Start date: January 19, 2019
Phase:
Study type: Observational [Patient Registry]

The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group. We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.

NCT ID: NCT03727568 Active, not recruiting - Clinical trials for Interstitial Lung Disease

Study Comparing Two Different Methods of Cryobiopsy in the Interstitial Lung Diseases

Start date: September 11, 2018
Phase: N/A
Study type: Interventional

Interstitial lung diseases (ILD) are a heterogeneous collection of more than 100 different pulmonary disorders. Surgical lung biopsie in combination with multidisciplinary discussion is recommend in combination to reach a consensus diagnosis when the initial clinical evaluation is inconclusive in the diagnosis of ILD. Cryobiopsy via bronchoscopy is approved for lung biopsies and allows harvesting of large tissue samples of excellent. This technique is not jet standardized. In this prospective randomised study the investigators want to evaluate the diagnostic yield comparing two different techniques of performing transbronchial cryobiopsy. In this study would be compared a shorter freezing time and more number of biopsies vs a longer freezing time and less number of biopsies.

NCT ID: NCT03560154 Active, not recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Effects of Whole Body Vibration Training in Patients With Interstitial Lung Disease

Start date: January 2017
Phase: N/A
Study type: Interventional

Interstitial lung disease (ILD) is a diverse group of parenchymal lung disorders characterized by restrictive lung function and impaired alveolar diffusion capacity, leading to dyspnea on exertion, reduced exercise endurance, and poor quality of life. Patients usually complain of progressive breathlessness, persisting non-productive cough, which occurs with exercise. Hemoptysis, fever, chest pain are also seen. The most common comorbidity in chronic lung diseases is the progressive loss of exercise tolerance. Not only dyspnea, but also peripheral muscle dysfunction and cognitive deficits such as, anxiety and depression are responsible for the reduction of mobility in the patient. In the context of pulmonary rehabilitation (PR) program to be applied in interstitial lung diseases; upper and lower limb endurance, stretching and relaxation techniques, aerobic exercise training, respiratory muscle training, training of energy conservation methods, support by determining oxygen requirement, nutritional evaluation, prevention of weight and muscle loss, psycho-social support. The purpose of PR programs in this disease is; to improve muscle strength, endurance, and mechanical activity, to improve dyspnea sensation, to improve functional capacity, to inform and educate the patient about the patient's disease. The use of whole body vibration (TVT) is an increasingly common method of therapeutic use in order to improve neuromuscular performance. TVT applications have shown that increases muscle activity, muscle strength and muscle strength, improves lower extremity blood circulation and balance, and increases growth hormone production. TVT training effects have rarely been studied in patients with pulmonary disease. Muscle strength and performance enhancement were significant effects of TVT, which was emphasized as a promising exercise method for those with chronic obstructive pulmonary disease (COPD). Over the past decade, endurance and strength training has been established as the most important components of exercise training programs in patients with COPD and ILD. Therefore, inclusion of TVT into exercise training programs in ILD patients may lead to beneficial results. The investigators hypotheses are: 1. the combination of home respiratory exercises with whole body vibration training may lead to more improved respiratory muscle strength, dyspnoea, functional capacity, balance, peripheral muscle strength and quality of life in ILD patients 2. when applied as an isolated intervention, home respiratory exercises programme may lead to lower results than combination programs.

NCT ID: NCT03485378 Active, not recruiting - Clinical trials for Non Small Cell Lung Cancer

Assessment of Precision Irradiation in Early NSCLC and Interstitial Lung Disease

ASPIRE-ILD
Start date: September 20, 2018
Phase: N/A
Study type: Interventional

This is a prospective phase II study of Stereotactic Ablative Radiotherapy (SABR) in patients with Non-Small Cell Lung Cancer (NSCLC) and co-existent Interstitial Lung Disease (ILD), to determine oncologic and toxicity outcomes. Patients will be divided into 3 separate cohorts based on the ILD-GAP index.

NCT ID: NCT03295279 Active, not recruiting - Lung Cancer Clinical Trials

WTC Chest CT Imaging Archive

Start date: September 1, 2012
Phase:
Study type: Observational

Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai Medical Center between 2003 and 2016. The clinical team sought to assess all findings suggestive of airway, interstitial, and neoplastic disease in a systematic way, and correlate those findings with clinical, functional, and exposure indicators. The study team's research will also involve analyses of longitudinal imaging and functional trends, and characterization of the WTC related lower airway diseases and their risk factors, with a focus on obesity-related imaging markers. The study team also plans to characterize the transitions into chronic obstructive pulmonary disease (COPD) among these workers.

NCT ID: NCT03215927 Active, not recruiting - Clinical trials for Interstitial Lung Disease

Abatacept for the Treatment of Myositis-associated Interstitial Lung Disease

ATtackMy-ILD
Start date: June 1, 2017
Phase: Phase 2
Study type: Interventional

A randomized, controlled pilot trial to evaluate the efficacy and safety of subcutaneous Abatacept in treating interstitial lung disease associated with the anti-synthetase syndrome.