Cardiovascular Vulnerability to Particulate Exposure

Status Completed

Clinical Trial Summary

This project is part of a program project directed toward assessing cardiac effects of particulate and other ambient air pollutants. In this project active elderly adults living in the communities of Boston and Steubenville have attended 12 weekly sessions including approximately 40 minutes of Holter monitoring, blood pressure, and oximetry evaluation before, during, and after outdoor exercise. To investigate the relation of air pollution to cardiac and pulmonary rehabilitation, a second portion of this study involves abstraction of blood pressure and symptom data and downloading of available repeated measures telemetry data in two populations. These populations include: 1) 200 outpatients attending 8 to 36 repeated weekly exercise training sessions in a major hospital cardiac rehabilitation unit.

Clinical Trial Description

Approximately 60 subjects have participated fully in Boston and Steubenville in the repeated 40 minute measurement of continuous EKG (Holter), blood pressure, and oximetry. In Steubenville we have also measured exhaled nitrogen oxide, an index of pulmonary inflammation. The exposure monitoring has included outdoor particle mass of PM2.5, outdoor gaseous pollutants, and indoor home and personal monitoring to evaluate the indoor contribution of pollution to health effects. ;

Study Design

Observational Model: Defined Population, Time Perspective: Longitudinal

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00013949
Study type	Observational
Source	National Institute of Environmental Health Sciences (NIEHS)
Contact
Status	Completed
Phase	N/A
Start date	September 1998
Completion date	September 2004

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03481322` - Low Sodium Cooking Study	N/A
Completed	`NCT00001638` - Magnetic Resonance Imaging of the Blood Vessels of the Heart
Completed	`NCT02376244` - The Health Impact of High Intensity Exercise Training With Intervals During Cardiac Rehabilitation	N/A
Completed	`NCT02523144` - Dexmedetomidine in Children Having Transthoracic Echocardiography	Phase 4
Completed	`NCT02277379` - Prediction of Bleeding and Transfusion Outcomes and Assessment of Perioperative Platelet Reactivity in Cardiac Surgery	N/A
Completed	`NCT01871090` - Remote Device Interrogation In The Emergency Department	N/A
Completed	`NCT02045641` - Pleural and Pericardial Effusion Following Open Heart Surgery	N/A
Active, not recruiting	`NCT01400490` - Eicosapentaenoic Acid (EPA)and Docosahexaenoic Acid Study	N/A
Completed	`NCT01192360` - Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in Congenital Heart Disease and Lung Disease	Phase 3
Terminated	`NCT00935766` - Effect of Fish Oil (Omega-3 Fatty Acids) on Arteries	Phase 3
Completed	`NCT00745446` - The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation	N/A
Completed	`NCT00140816` - Dairy Products and Metabolic Effects (Norwegian Part)	N/A
Completed	`NCT00178620` - Pre-hospital Administration of Thrombolytic Therapy With Urgent Culprit Artery Revascularization	Phase 4
Completed	`NCT01952171` - The Genetic Basis of Congenital Heart Disease in Africa
Recruiting	`NCT02933892` - Benefit of Transradial Approach in Chronic Kidney Disease Population Undergoing Cardiac Catheterization	Phase 4
Withdrawn	`NCT02838355` - Employing End Tidal Capnography in Continuous Flow Ventricular Assist Device Patients	N/A
Completed	`NCT02923518` - Cardiac Screening of Middle Aged and Older Women and Men (Master Athletes)
Terminated	`NCT02282163` - Evaluation of Safety and Efficacy of Lumason in Pediatric Echocardiography	Phase 3
Active, not recruiting	`NCT02260466` - Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.	N/A
Completed	`NCT02274220` - Feeding Study - Effects Post-cardiac Surgery	N/A