Lung Carcinoma Clinical Trial
Official title:
Evaluation of 4D-contrast Enhanced PET-CT in Tumour Volume Definition for Patients With Lung, Lower Oesophageal and Pancreatic Carcinomas.
The aim of high dose radiotherapy treatment is to deliver enough radiation to the tumour to
kill all the cancer cells while at the same time giving a low dose of radiation to the
normal parts of the body to reduce the side effects of treatment. This requires the cancer
specialist to accurately identify the areas of cancer on a computed tomography (CT) scan.
Positron emission tomography computed tomography (PETCT) scans use radioactive sugar that is
injected into the patient. This sugar goes into cancer cells and shows up as a bright spot
on the PET scan, allowing the doctors to see tumours more accurately. Some cancers move with
breathing, for example lung, pancreas and oesophageal (or gullet) cancers. Fourdimensional
CT scanning (4DCT) is a special type of CT scan that allows the motion of the tumour to be
seen and measured accurately. This information can then be used to help ensure that the
radiotherapy correctly treats the moving tumour.
The aim of this study is to see if there are possible benefits to combining PET with 4DCT to
get a 4D PETCT scan for tumours that move with breathing. This study is divided into three
cancer types; lung, lower oesophagus and pancreatic cancer.
First the investigators are going to test the use of 4D PETCT in the radiotherapy planning
of these tumours to see if it helps the doctor to identify the cancer.
Secondly, the investigators are going to see if the 4D PETCT helps to show areas within the
cancer that are potentially more active. This might then allow us to target a higher dose to
these areas, which could potentially improve the chance of controlling and curing the
cancer. Patients' standard treatment will not be altered by participating in the study.
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