Clinical Trials Logo
  1. Home
  2. Other
  3. NCT02093247

Characterize Novel Pathogen- and Host- Related Factors in Hospitalized Patients and Patients on the Emergency Department Presenting With Lower Respiratory Tract Infections and/or Sepsis

Lower Respiratory Tract Infection Clinical Trial

Clinical Trial Summary

This study is Observational multi-center, prospective study to characterize novel pathogen- and host-related factors in hospitalized patients and patients in the Emergency Department (ED) presenting with lower respiratory tract infections (LRTI) and/or sepsis.The Study's objective is to develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.

Clinical Trial Description

The TAILORED-Treatment consortium was established to develop new tools aimed to increase the effectiveness of antibiotic and antifungal therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in children and adults.

In reality, targeted antimicrobial therapy can most effectively be achieved by utilizing personalized data to facilitate a tailored and optimized approach to individual patient treatment. This can best be achieved by utilizing knowledge gained from both host-centered and pathogen-centered parameters during health and disease. Unfortunately, these parameters have traditionally, tended to be measured independently (for example using microbial culture or PCR-based methods for microbial detection, or measurement of the immune response to infections and/or blood-based biomarkers in the host), and used on an ad hoc basis without careful integration for the best treatment of the patient. However, recent advances in the development of high-throughput and sensitive molecular-based technologies, on-line internet database access tools, and bioinformatics analysis, now means that the goal of personalized medicine and treatment is in sight. Unfortunately however, there currently exists a technological gap between recent state-of-the-art methodologies (for example with respect to gaining new insights into novel host-pathogen interactions) and laboratory-to-bedside results to benefit patients, physicians and society as a whole. The TAILORED-Treatment project is designed to bridge this technological gap in order to generate novel insights and innovations that are readily exploitable for the maximum benefit of multiple stakeholders in the field of personalized medicine and infectious diseases. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02093247
Study type Observational
Source Hadassah Medical Organization
Contact
Status Not yet recruiting
Phase N/A
Start date June 2014
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06016244 - Safe, Effective and Cost-Effective Oxygen Saturation Targets for Children and Adolescents With Respiratory Distress: a Randomized Controlled Trial N/A
Recruiting NCT03391076 - The Clinical Value of FA in AHLRI Patients N/A
Completed NCT03694392 - Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 Years
Completed NCT01952470 - Preliminary Study of Dornase Alfa to Treat Chest Infections Post Lung Transplant. Phase 2
Recruiting NCT02929680 - Clinical Evaluation of FilmArray LRTI Panel N/A
Completed NCT01931254 - Assess a Diagnostic Tool to Distinguish Between Bacterial and Viral Infection N/A
Completed NCT02454114 - HOME FIRST Pilot: a Study of Early Supported Discharge in Patients With Lower Respiratory Tract Infections N/A
Completed NCT00975780 - A Trial to Reduce Pneumonia in Nursing Home Residents Phase 3
Completed NCT00350987 - Procalcitonin Guided Antibiotic Therapy and Hospitalisation in Patients With Lower Respiratory Tract Infections: The "ProHOSP" Study N/A
Completed NCT00420966 - Utilization and Compliance of Respiratory Syncytial Virus Monoclonal Antibody Therapy
Recruiting NCT06210282 - The Effect of Focused Lung Ultrasonography on Antibiotic Prescribing in General Practice N/A
Recruiting NCT05110261 - Evaluate the Safety and Efficacy of Nirsevimab in Healthy Preterm and Term Infants in China Phase 3
Recruiting NCT01985620 - The Impact of a Short Intervention During RSV Prophylaxis on Influenza Vaccination Rate. N/A
Recruiting NCT05374070 - Antiviral Activity of Oral Probiotics N/A
Recruiting NCT03808922 - Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study Phase 3
Not yet recruiting NCT03846401 - Bronchoscopy in Lower Respiratory Tract Infection in Respiratory Intensive Care Unit
Completed NCT01048073 - Non-influenza Etiologies of Acute Respiratory Illness in Southeast Asia N/A
Completed NCT00707941 - Oseltamivir Randomised Controlled Efficacy Trial Phase 3
Recruiting NCT03446534 - The Norwegian Antibiotics for Pneumonia in Children Study Phase 4
Completed NCT04311320 - A Low-Resource Oxygen Blender Prototype for Use in Modified Bubble CPAP Circuits N/A