Cognitive Dysfunction Clinical Trial
Official title:
Brain-derived Neurotrophic Factor: A Link to Obesity, Insulin Resistance and Cognitive Dysfunktion?
Individuals with type 2 diabetes have an increased risk of developing cognitive dysfunction
followed by dementia in late life. Obesity, physical inactivity and "systemic low-grade
inflammation" are strong risk factors and play a crucial role in this network of diseases.
Brain-derived Neurotrophic factor (BDNF) is produced in brain as well as several tissues
outside brain eg muscle cells. Low BDNF are associated with cognitive dysfuction, obesity
and type 2 diabetes.
The investigators include 200 individuals divided into three groups: 80 individuals with
type 2 diabetes, 80 age and BMI-matched controls and 40 individuals with impaired glucose
tolerance.
The project will test the hypothesis, that low systemic BDNF are associated with
accumulation of abdominal fat, cognitive dysfunction and insulin resistence with different
effect in men and women.
Methods:
200 individuals in age 40-65 years are recruited and categorized into 3 groups: 1. Type 2
Diabetes, 2. Impaired glucose Tolerance and 3. Normal Glucose Tolerance. Groups are supposed
to be age and BMI-matched.
Measurements of systemic BDNF, cogntive function (memory, attention and langue), fitness,
bodycomposition, glucose metabolism and systemic inflammation are done.
Multiple regression analysis are perfomed to explain variablity in cognitive function, with
age, visceral fat and BDNF as explanotory varibales.
;
Observational Model: Cohort, Time Perspective: Cross-Sectional
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