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Clinical Trial Summary

Bowel dysfunction is common after a restorative rectal cancer resection. Neoadjuvant radiotherapy is an influential factor that impairs bowel function and quality of life. However, almost half patients who have received primary surgery with preoperative radiotherapy are able to restore a good or moderate bowel function in the long term. This multicenter observational study aims to identify the risk factors of severe bowel dysfunction after rectal cancer resection and neoadjuvant radiotherapy, in accordance with the LARS score, and to build a model that predicts long-term major LARS in the early stage of follow-up. Development and validation cohorts are enrolled from tertiary hospitals in China.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05129215
Study type Observational
Source Sixth Affiliated Hospital, Sun Yat-sen University
Contact
Status Completed
Phase
Start date March 6, 2020
Completion date October 31, 2022

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