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Low Anterior Resection Syndrome clinical trials

View clinical trials related to Low Anterior Resection Syndrome.

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NCT ID: NCT04758195 Recruiting - Clinical trials for Low Anterior Resection Syndrome

Transanal Irrigation to Prevent Major Low Anterior Resection Syndrome

TAILARS
Start date: March 1, 2021
Phase: N/A
Study type: Interventional

Bowel dysfunction after rectal cancer resection comprises a vast array of bowel symptoms and associated quality-of-life impairment, collectively termed as low anterior resection syndrome (LARS). There are 40%-60% patients who suffer from major LARS after sphincter-preserving surgery. No consensus exists for LARS treatment or prevention. Transanal irrigation (TAI) was reported to play a helpful role in the management of major LARS and fecal incontinence. However, the preventive effect and daily accessibility need further confirmation. In this randomized trial, TAI compared with best support treatment, is used in patients who received curative low anterior resection for rectal cancer with diverting stoma, after completion of the stoma reversal. The primary outcome is the occurrence of major LARS after 6 months of the treatment.

NCT ID: NCT04688242 Recruiting - Clinical trials for Low Anterior Resection Syndrome

Anal Dilatation Plus Probiotics Before Ileostomy Reduction for Low Anterior Resection Syndrome

PILLARS
Start date: February 20, 2021
Phase: Phase 2
Study type: Interventional

This is randomized, phase 2 trial in patients with rectal cancer undergoing sphincter-preserving proctectomy and temporary ileostomy, to explore the effects of anal dilatation plus probiotics administered per anus before ileostomy reduction in relieving postoperative bowel dysfunction known as low anterior resection syndrome (LARS).

NCT ID: NCT04612569 Recruiting - Rectal Cancer Clinical Trials

Feasibility and Impact of a Prehabilitation and Rehabilitation Program for the Continuity of Care in Severe Low Anterior Resection Syndrome.

PRELARS
Start date: October 1, 2020
Phase:
Study type: Observational

Patients with sphincter saving procedures of rectal cancer usually experience intestinal dysfunction, including difficulty emptying the bowel and faecal incontinence, leading to a detriment in the quality of life. A prospective study is proposed to measure de feasibility and the impact of a continuous care programme for the prevention or reduction of intestinal dysfunction disorders. The intervention lies on prehabilitation and rehabilitation with physiotherapy, biofeedback and neuromodulation, is assisted by a telematic information system (APP for the monitoring of education on physiotherapy and surveillance).

NCT ID: NCT04591821 Completed - Rectal Cancer Clinical Trials

Bowel Dysfunction 3 Years After Anterior Resection a in a Swedish National Cohort

Start date: February 15, 2018
Phase:
Study type: Observational

The primary objectives are to evaluate the prevalence of LARS and Quality of Life in rectal cancer patients 3 years after anterior resection, to investigate if anastomotic technique is a risk factor for major LARS and to study the prevalence of colostomy 3 years after anterior resection and evaluate stoma function according to the stoma scale in EORTC QLQ-CR29.

NCT ID: NCT04586634 Completed - Clinical trials for Low Anterior Resection Syndrome

Randomized Clinical Trial on Transanal Irrigation

Start date: January 21, 2020
Phase: N/A
Study type: Interventional

Objective The primary objective is to demonstrate superiority of the Peristeen cone catheter compared to standard of care. The secondary objective is to investigate quality of life and different benefits and aspects of treatment and satisfaction with the Peristeen cone catheter. Design of the investigation This is a randomised, open-label, parallel investigation comparing the Peristeen cone catheter with standard of care in subjects with major LARS (LARS score ≥ 30). Each subject will be enrolled for a study duration of 12 weeks. Subjects will be randomized to the treatments stratified by neo-adjuvant radiotherapy. The comparator in this study will be current standard of care for patients with LARS which is conservative bowel management. This is defined as: Supportive therapy according to the individual treatment protocols available at each participating site. Primary endpoint and secondary endpoints Primary endpoint: • LARS score, obtained from the LARS score questionnaire* Secondary endpoints: - Number of subjects with Major LARS* - FIQL Score - scale 1, Modified American Society for Colorectal Surgeons Questionnaire* - FIQL Score - scale 2, Modified American Society for Colorectal Surgeons Questionnaire* - FIQL Score - scale 3, Modified American Society for Colorectal Surgeons Questionnaire* - FIQL Score - scale 4, Modified American Society for Colorectal Surgeons Questionnaire* - EQ-5D-5L - utility score* - EQ-5D-5L - VAS score (scale 0-10 cm)* - Satisfaction with treatment (scale 0-10 cm)* - Number of adverse events* *All endpoints are measured per subject at study termination

NCT ID: NCT04469426 Recruiting - Clinical trials for Patient Satisfaction

Interactive Online Informational and Peer Support App for Patients With Low Anterior Resection Syndrome

Start date: August 15, 2020
Phase: N/A
Study type: Interventional

After surgery for rectal cancer, many people undergo changes in bowel habits, which may include the need to empty their bowels more often, accidental leakage of stool or gas, the sudden urge to go to the bathroom, and more. The term "Low Anterior Resection Syndrome" or LARS is used to describe these symptoms. LARS has a negative impact on one's quality of life, and can lead to frustration, as there is no single intervention that has proven to be effective for LARS, and each patient has to undergo trial and error to find one's solution. As people struggle with LARS, they describe feeling hopeless and isolated. Peer support is a supportive relationship between individuals who share common experiences or face similar challenges. The goal of our study is to evaluate whether use of an online peer support application with trained mentors who themselves have lived or are living with LARS will empower patients to better manage their LARS symptoms and improve their quality of life.

NCT ID: NCT04279080 Completed - Clinical trials for Low Anterior Resection Syndrome

LARS in Ovarian Cancer Patients

Start date: January 1, 2003
Phase:
Study type: Observational

Background: Low anterior resection syndrome (LARS) is a common functional disorder after low anterior resection impacting quality of life. Data on LARS derives nearly exclusively from rectal cancer studies. Therefore, the study was designed to assess LARS in advanced epithelial ovarian cancer (EOC) patients, who underwent rectal resection and to compare it with a female rectal cancer cohort. Methods: A cross-sectional multi-centre analysis was performed for female patients suffering from either rectal or EOC who received a low anterior resection as part of their therapy regimen. None of the patients received pre- or postoperative radiotherapy. LARS was defined by using the validated LARS score and its severity was divided into "no", "minor" and "major LARS".

NCT ID: NCT04114591 Completed - Cancer Clinical Trials

Contributing Factors to Anterior Resection Syndrome and Its Impact on Quality of Life: A Retrospective Cohort Study

Start date: July 1, 2018
Phase:
Study type: Observational

This study adds to the understanding of the contributing factors leading to LARS, the long term effects of this syndrome post-operatively and its impact on quality of life.

NCT ID: NCT04087421 Recruiting - Rectal Cancer Clinical Trials

Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome

Start date: September 17, 2019
Phase: Phase 3
Study type: Interventional

The study is a multicentre randomized controlled trial with the objective to compare the effect of transanal irrigation with glycerol suppositories in patients suffering from major Low Anterior Resection Syndrome (LARS).

NCT ID: NCT04066894 Terminated - Clinical trials for Low Anterior Resection Syndrome

Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study

Start date: April 12, 2019
Phase: Phase 2
Study type: Interventional

This phase II trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to nearby tissues or lymph nodes, or other pelvic cancer. Sacral nerve stimulation is a permanent implant that may improve bowel functions by stimulating the nerves that control the muscles related to bowel function.