Long QT Syndrome Clinical Trial
Official title:
The Long QT Syndrome in Pregnancy
Long QT Syndrome (LQTS) is a disease of young adults and can affect women of child bearing
age. Suffers of LQTS are at risk of ventricular dysrhythmias including torsades de pointes
and ventricular fibrillation.
Pregnancy increases the chance that any mother may have an abnormal heart rhythm or
arrhythmia. This chance is higher with the LQTS. There are only a few reported cases of
women with the LQTS having a baby in the medical literature. This can make it difficult for
the doctor caring for a pregnant woman with the long QT syndrome - especially should they
need an anesthetic.
We would like to study as many women who have had a baby who have the long QT syndrome to
give us a better idea of whether there are any arrhythmias occurring at the time of
delivery.
This will be a retrospective analysis of all LQTS women managed at St. Paul's or BC Women's who have been pregnant in the last 5 years. These two hospitals both have a provincial role in the care of pregnant women, BC Women's as the designated provincial tertiary maternity care referral centre, and St. Paul's through its provincial PATCH clinic. Using the data from these two centres should capture the majority of LQTS cases in parturients in the province. We will search for these women from the Department of Anesthesia BC Women's consult database, the St. Paul's Cardiac Obstetrical Care database, and BC Women's Health Records using International Classification of Diseases - 10 coding for long QT. Then, after obtaining patient consent, review the charts collecting data using the data entry form. The cases will then be compared and any conclusions into the different anesthetic managements made. ;
Observational Model: Cohort, Time Perspective: Retrospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04169100 -
Novel Form of Acquired Long QT Syndrome
|
Phase 4 | |
| Completed |
NCT01648205 -
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients
|
Phase 2 | |
| Recruiting |
NCT06087367 -
Building of a Diagnostic/Prognostic Database for Human ERG Variant Effects
|
||
| Recruiting |
NCT04675788 -
Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening
|
Phase 4 | |
| Completed |
NCT05759962 -
Phase 1 Study of LQT-1213 in Healthy Adults
|
Phase 1 | |
| Enrolling by invitation |
NCT05903313 -
A Study to Evaluate Accuracy and Validity of the Chang Gung ECG Abnormality Detection Software
|
||
| Terminated |
NCT02439645 -
A Registry to Determine the Clinical and Genetic Risk Factors for Torsade De Pointes
|
||
| Recruiting |
NCT00221832 -
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases
|
N/A | |
| Completed |
NCT04706104 -
QT Measurement Techniques and Anesthesia Management
|
||
| Recruiting |
NCT04336644 -
Continuous Versus Intermittent cARdiac Electrical moNitorinG
|
N/A | |
| Recruiting |
NCT02814981 -
Hydroxyzine and Risk of Prolongation of QT Interval
|
N/A | |
| Completed |
NCT02876380 -
Prospective Identification of Long QT Syndrome in Fetal Life
|
||
| Completed |
NCT02425189 -
The Canadian National Long QT Syndrome Registry
|
||
| Completed |
NCT00399412 -
ECG Signal Collection From Long QT Syndrome, Wide QRS Complexes, Heart Failure, and Cardiac Resynchronization Patients
|
N/A | |
| Completed |
NCT02513940 -
Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes
|
Phase 4 | |
| Completed |
NCT02441829 -
Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Renal Function
|
Phase 1 | |
| Completed |
NCT03182777 -
Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies
|
N/A | |
| Completed |
NCT01849003 -
Study of the Effect of GS-6615 in Subjects With LQT-3
|
Phase 1 | |
| Completed |
NCT00316459 -
Study Evaluating the Effects of Multiple Oral Doses of ERB-041 on Cardiac Repolarization in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT00292032 -
Registry of Unexplained Cardiac Arrest
|