Logopenic Progressive Aphasia Clinical Trial
Official title:
rTMS for the Improvement of Language Functioning in the Logopenic Variant of Primary Progressive Aphasia; a Feasibility and Tolerability Pilot Study
Verified date | March 2021 |
Source | University of Manitoba |
Contact | Benjamin Meek |
Phone | 2042372677 |
rtms[@]sbgh.mb.ca | |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to investigate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) - a form of non-invasive brain stimulation - to improve language functioning in individuals who have the logopenic variant of primary progressive aphasia (PPA-L) - a slowly progressive impairment of language, characterized by difficulties with word-finding, sentence repetition and sentence comprehension.
Status | Recruiting |
Enrollment | 10 |
Est. completion date | December 2022 |
Est. primary completion date | August 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Diagnosis of PPA-L (confirmed by a neurologist or neuropsychiatrist who has observed the patient for at least one year); - Mild to moderate language impairment as assessed by the Druks and Masterson Naming Task; - Native English speaker. Exclusion Criteria: - Cerebrovascular disorders, hydrocephalus or intra-cranial mass, documented by MRI; - History of traumatic brain injury, seizures, or another neurological disease; - Significant medical problems (e.g. poorly controlled diabetes or hypertension or cancer within the past 5 years); - Major depressive disorder, bipolar disorder, schizophrenia, substance use disorder or mental retardation according to the criteria of the DSM-IV; - Any contraindication for rTMS (e.g., implanted metal devices; cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps, metal in the body [rods, plates, screws, shrapnel, dentures, IUD] or metallic particles in the body, surgical clips in the head, previous neurosurgery, cochlear implants, prosthetic heart valves); - Currently pregnant or breastfeeding. |
Country | Name | City | State |
---|---|---|---|
Canada | St. Boniface Hospital | Winnipeg | Manitoba |
Lead Sponsor | Collaborator |
---|---|
University of Manitoba |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in score on the Druks and Masterson Naming Task | Assessment of change in language function as a result of rTMS intervention. Minimum score = 0. Maximum score = 24. Higher scores indicate better naming performance. | One week pre- and one week post-rTMS treatment |
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