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Induction Chemotherapy Followed by Short Course Radiotherapy in Rectal Cancer

Rectal Cancer Clinical Trial

Official title:
Induction Chemotherapy With FOLFIRINOX ( 5 Fluorouracil, Oxaliplatine and Irinotecan) Followed by Short Course Radiotherapy in Locally Advanced Rectal Cancer

Clinical Trial Summary

A Single-arm phase II trial evaluating induction chemotherapy with FOLFIRINOXm followed by short course radiotherapy (RT) in locally advanced rectal carcinoma

Clinical Trial Description

Total neoadjuvant treatment (TNT) is currently the standard of care in the management of locally advanced rectal cancer since recent studies have shown improved pathological complete response and disease-free survival with this approach. However, survival benefits remain unproven. Two strategies of TNT are validated so far : induction chemotherapy with FOLFIRINOX followed by long course radio-chemotherapy (RCT) or short course RT (5x5 Gy) followed by consolidation chemotherapy with CAPOX (capecitabine and oxaliplatin) or FOLFOX (5 FU and oxaliplatin) . The objective of investigators is to evaluate pathological complete response with a new strategy of TNT consisting in induction chemotherapy with FOLFIRINOXm followed by short course RT and a delayed surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05868317
Study type Interventional
Source Salah Azaïz Cancer Institute
Contact
Status Active, not recruiting
Phase Phase 2
Start date November 1, 2020
Completion date November 30, 2023
View Details
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