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Double/Triple Combinations of AN2025, AN0025 and Atezolizumab in Advanced Solid Tumors

Locally Advanced Solid Tumor Clinical Trial

Official title:
An Open-Label, Multicenter, Phase 1a Study of AN2025 and AN0025 in Double Combination With Atezolizumab and in Triple Combination With Atezolizumab in Patients With Advanced Solid Tumors

Clinical Trial Summary

This is an open-label, multicenter, Phase 1a study to evaluate the safety, tolerability, PK and preliminary efficacy of AN2025 and AN0025 in double or triple combination treatments with Atezolizumab in patients with locally advanced/metastatic tumors.

Clinical Trial Description

This is an open-label, multicenter, Phase 1a study to evaluate the safety, tolerability, PK and preliminary efficacy of AN2025 and AN0025 in double or triple combination treatments with Atezolizumab in patients with locally advanced/metastatic tumors. This study consists of three DLT Observation Periods I, II and III. Observations I and II are double combination treatments, which will be conducted in parallel, whereas Observation III (the triple combination treatment) will be initiated only after a thorough review of the safety data from Observations I and II. In all three Observation Periods, a "6 + 3 design" will be utilized for dose finding with dose escalation and de-escalation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04975958
Study type Interventional
Source Adlai Nortye Biopharma Co., Ltd.
Contact Robert Atkinson, PhD, MSCR
Phone 1-919-741-8894
Email robert.atkinson@adlainortye.com
Status Recruiting
Phase Phase 1
Start date September 7, 2021
Completion date June 2024
View Details
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