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Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for Recurrence — ICONA  

Locally Advanced Rectal Cancer Clinical Trial

Official title:
Induction Versus Consolidation Chemotherapy in Total Neoadjuvant Therapy of Localy Advanced Rectal Cancer With High Risk of Recurrence (ICONA Study)

Clinical Trial Summary

The purpose of the study is to identify the most promising sequence of modalities in total neoadjuvant treatment of localy advanced rectal cancer with high risk of recurrence

Clinical Trial Description

International recommendations for the treatment of LARC with a high risk of disease recurrence are inconsistent, regarding TNT. In Germain randomised study more pCR were achieved with consolidation chemotherapy. We will compare our standard approach (induction plus consolidation CT) with consolidation CT. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05054959
Study type Interventional
Source Institute of Oncology Ljubljana
Contact Vaneja Velenik, PhD
Phone +386 15879297
Email vvelenik@onko-i.si
Status Recruiting
Phase Phase 2
Start date June 24, 2021
Completion date December 31, 2027
View Details
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