Painless Local Anaesthesia With Bicarbonate Admixture

Status Completed

Clinical Trial Summary

This study examines whether the injection of local anesthesia mixed with sodium bicarbonate in the ratio of 3:1 creates a less burning sensation and is as effective regarding the anesthetic effect as in the ratio of 9:1.

Clinical Trial Description

Therefore the investigators compare two groups with 24 healthy individuals in each group in a cross-over study. One group receives four injections (two in each forearm) and one group receives only two injections (one in each forearm)

The four injections of group 1 are:

- IMP1: Lidocaine and sodium bicarbonate ratio 3:1

- IMP 2: Lidocaine and sodium bicarbonate ratio 9:1

- IMP 3: Lidocaine

- IMP 4: Sodium cloride 0.9% (=placebo)

The two injections of group 2 are IMP1 and IMP2.

After each injection the individual has to rate their pain sensation on a NRS scale and afterwards the anesthetic effect gets tested by a standardized laser application. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03238625
Study type	Interventional
Source	University of Zurich
Contact
Status	Completed
Phase	Phase 2
Start date	August 1, 2017
Completion date	October 18, 2017

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