Liver Transplantation Clinical Trial
Official title:
The Significance of Intact Liver Innervation for the Glucose and GLP-1 Induced Insulin Secretion
The aim of the study is to investigate the significance of intact nerve supply to the liver
for the glucagon-like peptide-1 (GLP-1) induced insulin secretion.
The hypothesis is that the effects of GLP-1 is transmitted through the GLP-1 receptor and
that these effects involve sensory afferent neurons, probably primarily parasympathetic.
GLP-1 is a potent enterogastron and incretin hormone. It is rapidly inactivated by
dipeptidyl peptidase IV so only 10-15% enters the systemic circulation. This has led to the
hypothesis that GLP-1 interact locally with afferent sensory nerve fibers.
The aim of this study is to investigate the significance of intact liver innervation for the
GLP-1 induced insulin secretion in liver transplanted patients; kidney transplanted control
patients matched for immunosuppressive treatment, age, gender and body weight; and ten
control persons matched for age, gender and body weight.
The insulin secretion will be evaluated from blood samples that will be analyzed for insulin
and c-peptide.
;
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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