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Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients

Liver Transplant; Complications Clinical Trial

Official title:
The Efficacy of Intravenous Hydroxocobalamin Versus Methylene Blue as Treatment for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients

Clinical Trial Summary

This study will evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.

Clinical Trial Description

This randomized, prospective, open label, pilot study will involve 20 LT patients with intraoperative vasoplegic syndrome. If vasoplegic syndrome is identified via SVR lower than 500 dynes-sec/cm-5, the patients will be randomized to receiving either IV methylene blue or hydroxocobalamin (10 patients in each group). The primary end point will examine the efficacy of the two medications on treating intraoperative vasoplegic syndrome. The SVR, blood pressure, and amount of administered vasopressors at 0, 15, 30, 60, 90, 120, 150, and 180 minutes after the medication administrations will be recorded. . ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04054999
Study type Interventional
Source Mayo Clinic
Contact Sher-Lu Pai, MD
Phone 904-953-2000
Email pai.sherlu@mayo.edu
Status Recruiting
Phase Phase 4
Start date November 30, 2019
Completion date January 2024
View Details
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