Liver Metastases Clinical Trial
Official title:
Phase 2 Study: Functional Treatment Planning Utilizing 18-FDGal PET/CT in SBRT for Liver Metastases
Background: Anatomical (traditional) stereotactic body radio therapy(SBRT) treatment
planning assumes homogenous distribution of function in the normal liver tissue. In
functional treatment planning, additional information on distribution of the function
derived from functional imaging of normal tissue is taken into account. by functional
treatment planning it becomes possible to prioritize and spare the best functioning part of
an organ.
Aim: To test whether functional treatment planning based on 18-FDGal PET/CT may spare the
best functioning liver tissue.
Endpoints: Reduction in hepatic systemic clearance (K) in the dynamic 18-FDGal PET/CT scan
one month after SBRT compared to the baseline status in sub-volumes recieving 15 Gy or
higher. Secondly, the investigators will evaluate the toxicity to SBRT by a toxicity scoring
system that includes biochemical measures as well as symptomatic scores.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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