Sepsis Clinical Trial
Official title:
Microcirculation and Oxidative Stress in Critically Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when
multiple organ failure occurs, the mortality rate of patients increases dramatically.
Therefore, the major goal in the intensive care unit is to prevent the occurrence of
multiple organ failure. The sepsis protocol and early goal directed treatment have great
effects to reduce development of multiple organ failure and to decrease the mortality rate.
However, sometime the condition of patient deteriorated in spite of both the mean blood
pressure and mixed venous oxygen saturation are normal. Some experts recognize that there
might be microcirculatory dysfunction of tissue or organ. The dysfunction of
microcirculation might due to vasoconstriction or microthrombosis. Vasoconstriction might
result from systemic inflammation, reactive oxygen species, or dysfunction of synthesis of
NO (nitric oxide). Microthrombosis might result from systemic inflammation, reactive oxygen
species, imbalance of coagulatory system, or damage of endothelial cell.
In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute
lung injury, and acute respiratory distress syndrome. This study tries to investigate the
relation between oxidative stress and microcirculation. Furthermore, the investigators will
try to investigate the correlation between the severity of oxidative stress and
microcirculatory dysfunction and the severity of disease and prognosis. The investigators
hope this study will help them to figure out the picture of disease progression of patients.
It may conduct further study to modulate the oxidative stress, to improve the
microcirculatory function, and finally to improve the outcome of patients.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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