Inspiratory Muscle Training Post-Liver Transplant

Muscle Weakness Clinical Trial

Official title: Comparison of Inspiratory Muscle Training and Usual Care in Individuals Post-Liver Transplant

Status Completed

Clinical Trial Summary

Individuals with chronic liver disease develop significant muscle wasting that remains post-liver transplant. The transplant surgery additionally challenges respiratory mechanics. Respiratory muscle strength has been measured to be impaired in individuals post liver transplant. This study proposes an 8 week intervention designed to increase respiratory muscle strength and pulmonary function that we hypothesize will correlate to improved functional performance and quality of life post-liver transplant. Pre-test post-test design, that will randomize subjects into an experimental group that will receive the inspiratory muscle strengthening exercise in addition to usual post-liver transplant care and a control group that will only receive the usual post-transplant care. Up to 50 subjects will be recruited from the Post-Liver Transplant Outpatient Clinic at the Miami Transplant Institute. The subjects will have repeated measurements of respiratory muscle strength, pulmonary function, functional mobility performance, and quality of life at baseline, 4 weeks, and 8 weeks.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Liver Disease Chronic
• Liver Diseases
• Muscle Weakness
• Pulmonary Valve Insufficiency
• Respiratory Insufficiency

• NCT number: NCT03130608
• Study type: Interventional
• Source: University of Miami
• Status: Completed
• Phase: N/A
• Start date: June 30, 2017
• Completion date: May 31, 2021