Liver Cirrhosis Clinical Trial
Official title:
Prevelance of Fragmented QRS Complex and Prolonged QT Interval in Cirrhotic Patients and Its Correlation With the Severity of the Disease
.Cardiac affection in liver cirrhosis is a clinical condition characterized by impaired
diastolic relaxation and contractility with electrophysiological abnormalities.
.Cirrhotic patients with cardiac abnormality have higher mortality rates compared to
patients without cardiac affection.
The suggested pathophysiologic mechanisms of cardiac affection in cirrhotic patients are;
alterations in the beta-adrenergic signaling pathway and, myocardial fibrosis formation,
sympathetic nervous system activation and changes in ion channels.
.As a component of cardiac involvement in cirrhotic patients fragmented QRS complex and
prolongation of the corrected QT interval has been documented in most of the cases with
liver cirrhosis (LC) and its prevalence increases with the severity of the disease
.Cardiac affection in liver cirrhosis is a clinical condition characterized by impaired
diastolic relaxation and contractility with electrophysiological abnormalities.
.Cirrhotic patients with cardiac abnormality have higher mortality rates compared to
patients without cardiac affection.
The suggested pathophysiologic mechanisms of cardiac affection in cirrhotic patients are;
alterations in the beta-adrenergic signaling pathway and, myocardial fibrosis formation,
sympathetic nervous system activation and changes in ion channels.
.As a component of cardiac involvement in cirrhotic patients fragmented QRS complex and
prolongation of the corrected QT interval has been documented in most of the cases with
liver cirrhosis (LC) and its prevalence increases with the severity of the disease.
.Fragmented QRS (fQRS) is a convenient marker of myocardial scar evaluated by 12-lead
electrocardiogram (ECG) recording. fQRS is defined as additional spikes within the QRS
complex. In patients with CAD, fQRS was associated with myocardial scar detected by single
photon emission tomography and was a predictor of cardiac events. fQRS was also a predictor
of mortality and arrhythmic events in patients with reduced left ventricular function. The
usefulness of fQRS for detecting myocardial scar and for identifying high-risk patients has
been expanded to various cardiac diseases, such as cardiac cirrhosis, arrhythmogenic right
ventricular cardiomyopathy, acute coronary syndrome. fQRS can be caused by zigzag conduction
around the scarred myocardium, resulting in multiple spikes within the QRS complex .
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04533932 -
Endosonographic Shear Wave Elastography for Liver Stiffness
|
||
| Not yet recruiting |
NCT06031740 -
A Comparison of Flexible Endoscopic Polidocanol Liquid and Foam Sclerotherapy in Cirrhotic Patients With Bleeding From Internal Hemorrhoids
|
N/A | |
| Not yet recruiting |
NCT06026267 -
Efficacy of Conventional Dose Protocol vs Low Dose Protocol Albumin Use in Patients With Cirrhosis and High Risk Spontaneous Bacterial Peritonitis
|
N/A | |
| Not yet recruiting |
NCT06076330 -
Efficacy of 5% Albumin v/s Plasmalyte in Combination With 20% Albumin for Fluid Resuscitation in Cirrhosis With Sepsis Induced Hypotension
|
N/A | |
| Enrolling by invitation |
NCT05055713 -
A Randomized Controlled Study on the Treatment of Cirrhosis Combined With Hypersplenism
|
N/A | |
| Recruiting |
NCT04578301 -
Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
|
||
| Not yet recruiting |
NCT05515861 -
Evaluation of EUS in Preventing Rebleeding After Endoscopic Cyanoacrylate Injection for Gastric Varices
|
N/A | |
| Not yet recruiting |
NCT05120557 -
Point-of-care Ultrasound Screening and Assessment of Chronic Liver Diseases and NASH
|
N/A | |
| Not yet recruiting |
NCT03623360 -
Functional MRI to Determine Severity of Cirrhosis
|
||
| Not yet recruiting |
NCT02710227 -
Sleep Timing and Circadian Preferences in A Sample of Egyptian Patients With Hepatic Cirrhosis
|
N/A | |
| Completed |
NCT02917408 -
Retrospective Study About Primary Biliary Cholangitis During January 2001 to July 2016 at West China Hospital
|
||
| Active, not recruiting |
NCT02551250 -
Annual MRI Versus Biannual US for Surveillance of Hepatocellular Carcinoma in Liver Cirrhosis
|
||
| Recruiting |
NCT02239991 -
Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant
|
N/A | |
| Enrolling by invitation |
NCT02256514 -
Open Label Trial of Immunotherapy for Advanced Liver Cancer
|
Phase 2 | |
| Terminated |
NCT02311985 -
Comparison of Three Transfusion Strategies for Central Venous Catheterization in Cirrhotics: A Randomized Clinical Trial
|
N/A | |
| Terminated |
NCT01937130 -
Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF
|
Phase 2 | |
| Recruiting |
NCT01728688 -
Safety and Efficacy of Human Autologous Peripheral Blood Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01728727 -
Safety and Efficacy of Human Umbilical Cord Derived Mesenchymal Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01724697 -
Safety and Efficacy of Human Bone Marrow Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01618890 -
Hepatic Venous Pressure Gradient-guided Versus Standard Beta-blocker Therapy in Primary Prevention of Variceal Bleeding
|
Phase 3 |