Liver Cirrhosis Clinical Trial
Official title:
Prevelance of Fragmented QRS Complex and Prolonged QT Interval in Cirrhotic Patients and Its Correlation With the Severity of the Disease
.Cardiac affection in liver cirrhosis is a clinical condition characterized by impaired
diastolic relaxation and contractility with electrophysiological abnormalities.
.Cirrhotic patients with cardiac abnormality have higher mortality rates compared to
patients without cardiac affection.
The suggested pathophysiologic mechanisms of cardiac affection in cirrhotic patients are;
alterations in the beta-adrenergic signaling pathway and, myocardial fibrosis formation,
sympathetic nervous system activation and changes in ion channels.
.As a component of cardiac involvement in cirrhotic patients fragmented QRS complex and
prolongation of the corrected QT interval has been documented in most of the cases with
liver cirrhosis (LC) and its prevalence increases with the severity of the disease
.Cardiac affection in liver cirrhosis is a clinical condition characterized by impaired
diastolic relaxation and contractility with electrophysiological abnormalities.
.Cirrhotic patients with cardiac abnormality have higher mortality rates compared to
patients without cardiac affection.
The suggested pathophysiologic mechanisms of cardiac affection in cirrhotic patients are;
alterations in the beta-adrenergic signaling pathway and, myocardial fibrosis formation,
sympathetic nervous system activation and changes in ion channels.
.As a component of cardiac involvement in cirrhotic patients fragmented QRS complex and
prolongation of the corrected QT interval has been documented in most of the cases with
liver cirrhosis (LC) and its prevalence increases with the severity of the disease.
.Fragmented QRS (fQRS) is a convenient marker of myocardial scar evaluated by 12-lead
electrocardiogram (ECG) recording. fQRS is defined as additional spikes within the QRS
complex. In patients with CAD, fQRS was associated with myocardial scar detected by single
photon emission tomography and was a predictor of cardiac events. fQRS was also a predictor
of mortality and arrhythmic events in patients with reduced left ventricular function. The
usefulness of fQRS for detecting myocardial scar and for identifying high-risk patients has
been expanded to various cardiac diseases, such as cardiac cirrhosis, arrhythmogenic right
ventricular cardiomyopathy, acute coronary syndrome. fQRS can be caused by zigzag conduction
around the scarred myocardium, resulting in multiple spikes within the QRS complex .
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