Clinical Trials Logo
  1. Home
  2. Liver Cirrhosis
  3. NCT02484573

Evaluation of Intestinal Permeability in Cirrhotic Patients Before and After Treatment With Non-selective Beta Blocker (Propranolol)

Liver Cirrhoses Clinical Trial

Official title:
Evaluation of Intestinal Permeability in Cirrhotic Patients Before and After Treatment With Non-selective Beta Blocker (Propranolol)

Clinical Trial Summary

This study seeks to investigate whether non-selective beta blocker treatment decreases intestinal permeability in cirrhotic patients by altering the expression of genes encoding intercellular junction proteins.

Clinical Trial Description

There is evidence that the non-selective beta-blocker (NSBB) propranolol reduces intestinal permeability and decreases bacterial translocation in cirrhotic patients, independent of hemodynamic effects on portal pressure. The mechanism by which this decrease in intestinal permeability and bacterial translocation occurs has not been established. Among the proposed mechanisms are: modification of splanchnic hemodynamics, increased gastrointestinal motility, and immunological properties of nonselective beta blockade. It is not known, however, if beta-blocker treatment decreases intestinal permeability by altering the expression of genes encoding intercellular junction proteins. This study seeks to investigate this question to improve understanding of the mechanism by which beta-blockers work in primary and secondary prophylaxis of variceal hemorrhage. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02484573
Study type Interventional
Source Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Contact Aldo Torre Delgadillo, MD
Phone 525554870900
Email detoal@yahoo.com
Status Recruiting
Phase N/A
Start date May 2015
Completion date August 2020
View Details
See also
  Status Clinical Trial Phase
Terminated NCT03219372 - Pravastatin Intervention to Delay Hepatocellular Carcinoma Recurrence Phase 2
Recruiting NCT03624517 - Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices Phase 4
Recruiting NCT04057287 - Risk Factors of Liver Fibrosis Among First Degree Relatives of Patients With NASH Related Cirrhosis (NRC)
Recruiting NCT04089878 - "To Study the Impact of Balloon-occluded Retrograde Transvenous Obliteration (BRTO)/Plug Assisted Retrograde Transvenous Obliteration (PARTO) Mediated Portal Flow Modulation in Reduction of Ammonia and Improvement in Organ Volume and Functionality in Patients of Cirrhosis With LR Shunt N/A
Completed NCT04212286 - Comparing the Diagnostic Efficiencies of CEUS and EOB-MRI in Patients With High Risk of HCC N/A
Completed NCT04474743 - Malnutrition in Chronic Gastrointestinal Diseases, Cross-sectional Study
Recruiting NCT03694691 - Developing Viability Index for Machine Perfused Livers N/A
Terminated NCT04072601 - Statins for Prevention of Disease Progression and Hospitalization in Liver Cirrhosis Phase 4
Terminated NCT03878563 - Alterations in Intestinal Mucosal Barrier Visualized by Confocal Laser Endomicroscopy in Liver Cirrhosis: a Pilot Trial (AMBIC)
Terminated NCT04160039 - Early Cycle Ergometry for Critically-Ill Liver Failure Patients in a Transplant Intensive Care Unit N/A
Recruiting NCT04191369 - EGD vs EUS in Diagnosing Portal Hypertension in Cirrhotic Patients. N/A
Completed NCT03083925 - Viatorr CX Case-control Study for Complications of Portal Hypertension
Not yet recruiting NCT03855709 - Antibiotic-resistant Bacterial Infection of Hepatic Patients
Recruiting NCT04357600 - Umbilical Cord Mesenchymal Stem Cell for Liver Cirrhosis Patient Caused by Hepatitis B Phase 1/Phase 2
Completed NCT03156426 - Prognostic Biomarkers For Acute Kidney Injury In Liver Cirrhosis
Active, not recruiting NCT03868397 - Preoperative Portal and Splanchnic Flow Measurement Using MRI N/A
Terminated NCT03650660 - Concordance Between Echocardiographic Assessment Performed in the Initial Phase of Decompensated Cirrhosis With Edema and Ascites by an Expert Intensive Care Physician and a Non-expert Gastroenterologist
Completed NCT03871894 - Indirect Calorimeter Based Study in Patients With Liver Cirrhosis N/A
Completed NCT03283176 - Hematologic Profile, Vit. B12 and Folic Acid in Cirrhotics Received Sofosbuvir and Daclatasvir With or Without Ribavirin
Recruiting NCT03172273 - Early Use of TIPS With Polytetrafluoroethylene(PTFE) Covered Stents in Cirrhotic Patients With Refractory Ascites N/A