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Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant

Liver Cirrhosis Clinical Trial

Official title:
Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant

Clinical Trial Summary

A point-of-care bleeding management protocol based on global viscoelastic test (thromboelastometry) can change the amount of blood products used during orthotopic liver transplant.

Clinical Trial Description

Patients with liver disease frequently acquire a complex disorder of hemostasis secondary to their disease.

The fundamental key to the management of coagulopathy of cirrhotic patient is the knowledge that hepatic dysfunction results in impairment of both pro-hemostatic factors as anti-hemostatic factors in a disproportionate manner which can lead to a clinical picture of both bleeding and thrombosis.

Routine tests of coagulation as prothrombin time (PT, INR) and activated partial thromboplastin time (APTT) although prolonged in cirrhotic patients cannot predict bleeding.

Global viscoelastic test of whole blood (TEG / ROTEM) produce a dynamic composite image of the entire coagulation process and have the potential to provide clinically relevant information in patients with liver disease allowing rational use of blood products during liver transplantation. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02239991
Study type Interventional
Source Hospital Israelita Albert Einstein
Contact Luiz Henrique Ide Yamauchi, physician
Phone +55112151-7806
Email luizyamauchi@gmail.com
Status Recruiting
Phase N/A
Start date September 2014
Completion date February 2016
View Details
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