Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Other |
Donor associated variables - age |
Age of the donor (years) |
1 hour |
|
Other |
Donor associated variables - liver steatosis |
Assessment of liver steatosis (%) |
1 hour |
|
Other |
Donor associated variables - gender |
Gender of donor |
1 hour |
|
Other |
Donor associated variables - Body mass index |
Body mass index of donor (kilogram/meter2) |
1 hour |
|
Other |
Donor associated variables - weight of the liver |
Weight of the liver (gram) |
1 hour |
|
Other |
Ischemia time - warm |
Estimation of warm ischemia time (minutes) |
12 hour |
|
Other |
Ischemia time - cold |
Estimation of cold ischemia time (minutes) |
12 hour |
|
Other |
Donor associated variables - Donor risk index |
Donor risk index score - Increasing donor risk index is associated with higher discard rates among deceased donor livers procured for transplant. Low value of 1= best prognosis. High value of 40 = worst prognosis |
1 hour |
|
Primary |
Lactate level in microdialysate from hilar plate after normothermic machine perfusion - 4 hours |
Lactate level in microdialysate from hilar plate after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Lactate level in microdialysate from liver tissue after normothermic machine perfusion - 2.5 hours |
Microdialysis lactate level in donor liver tissue after 2.5 hours of normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Lactate level in microdialysate from liver tissue after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Microdialysis lactate level in donor liver tissue after 2 hours of Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Pyruvate level in microdialysate from liver tissue after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Microdialysis pyruvate level in donor liver tissue after 2 hours of Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Glycerol level in microdialysate from liver tissue after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Microdialysis glycerol level in donor liver tissue after 2 hours of Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Glucose level in microdialysate from liver tissue after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Microdialysis glucose level in donor liver tissue after 2 hours of Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Lactate level in microdialysate from liver tissue after controlled oxygenated rewarming machine perfusion - 1 hour |
Microdialysis lactate level in donor livers tissue after 1 hour of controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hour |
|
Secondary |
Glycerol level in microdialysate from liver tissue after controlled oxygenated rewarming machine perfusion - 1 hour |
Microdialysis glycerol level in donor livers tissue after 1 hour of controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hour |
|
Secondary |
Glucose level in microdialysate from liver tissue after controlled oxygenated rewarming machine perfusion - 1 hour |
Microdialysis glucose level in donor livers tissue after 1 hour of controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hour |
|
Secondary |
Pyruvate level in microdialysate from liver tissue after controlled oxygenated rewarming machine perfusion - 1 hour |
Microdialysis pyruvate level in donor livers tissue after 1 hour of controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hour |
|
Secondary |
Glucose level in microdialysate from liver tissue after normothermic machine perfusion - 2.5 hours |
Microdialysis glucose level in donor liver tissue after 2.5 hours of normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Glucose level in microdialysate from liver tissue after normothermic machine perfusion - 4 hours |
Microdialysis glucose level in donor liver tissue after 4 hours of normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Pyruvate level in microdialysate from liver tissue after normothermic machine perfusion - 2.5 hours |
Microdialysis pyruvate level in donor liver tissue after 2.5 hours of normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Pyruvate level in microdialysate from liver tissue after normothermic machine perfusion - 4 hours |
Microdialysis pyruvate level in donor liver tissue after 4 hours of normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Glycerol level in microdialysate from liver tissue after normothermic machine perfusion - 2.5 hours |
Microdialysis glycerol level in donor liver tissue after 2.5 hours of normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Glycerol level in microdialysate from liver tissue after normothermic machine perfusion - 4 hours |
Microdialysis glycerol level in donor liver tissue after 4 hours of normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Lactate level in microdialysate from bile after normothermic machine perfusion - 4 hours |
Microdialysis lactate level from bile after normothermic machine perfusion - 4 hours in extended criteria donors livers. |
4 hours |
|
Secondary |
Lactate level in microdialysate from bile after normothermic machine perfusion - 2.5 hours |
Microdialysis lactate level from bile after normothermic machine perfusion - 2.5 hours in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Glucose level in microdialysate from bile after normothermic machine perfusion - 4 hours |
Microdialysis glucose levels from bile after normothermic machine perfusion - 4 hours in extended criteria donors livers. |
4 hours |
|
Secondary |
Glucose level in microdialysate from bile after normothermic machine perfusion - 2.5 hours |
Microdialysis glucose levels from bile after normothermic machine perfusion - 2.5 hours in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Pyruvate level in microdialysate from bile after normothermic machine perfusion - 4 hours |
Microdialysis pyruvate levels from bile after normothermic machine perfusion - 4 hours in extended criteria donors livers. |
4 hours |
|
Secondary |
Pyruvate level in microdialysate from bile after normothermic machine perfusion - 2.5 hours |
Microdialysis pyruvate levels from bile after normothermic machine perfusion - 2.5 hours in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Glycerol level in microdialysate from bile after normothermic machine perfusion - 4 hours |
Glycerol levels from bile after normothermic machine perfusion - 4 hours in extended criteria donors livers. |
4 hours |
|
Secondary |
Glycerol level in microdialysate from bile after normothermic machine perfusion - 2.5 hours |
Glycerol levels from bile after normothermic machine perfusion - 2.5 hours in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Glycerol level in microdialysate from bile after controlled oxygenated rewarming machine perfusion - 1 hour |
Glycerol levels from bile after controlled oxygenated rewarming machine perfusion - 1 hour - in extended criteria donors livers. |
1 hour |
|
Secondary |
Glucose level in microdialysate from bile after controlled oxygenated rewarming machine perfusion - 1 hour |
Glucose levels from bile after controlled oxygenated rewarming machine perfusion - 1 hour - in extended criteria donors livers. |
1 hour |
|
Secondary |
Lactate level in microdialysate from bile after controlled oxygenated rewarming machine perfusion - 1 hour |
Lactate levels from bile after controlled oxygenated rewarming machine perfusion - 1 hour - in extended criteria donors livers. |
1 hour |
|
Secondary |
Pyruvate level in microdialysate from bile after controlled oxygenated rewarming machine perfusion - 1 hour |
Pyruvate levels from bile after controlled oxygenated rewarming machine perfusion - 1 hour - in extended criteria donors livers. |
1 hour |
|
Secondary |
Pyruvate level in microdialysate from bile after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Pyruvate levels from bile after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours - in extended criteria donors livers. |
2 hours |
|
Secondary |
Glycerol level in microdialysate from bile after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Glycerol levels from bile after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours - in extended criteria donors livers. |
2 hours |
|
Secondary |
Lactate level in microdialysate from bile after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Lactate levels from bile after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours - in extended criteria donors livers. |
2 hours |
|
Secondary |
Glucose level in microdialysate from bile after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Glucose levels from bile after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours - in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gases pH - 4 hours after normothermic machine perfusion |
Bile gas pH - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases pH - 2.5 hours after normothermic machine perfusion |
Bile gas pH - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases Lactate - 4 hours after normothermic machine perfusion |
Bile gas Lactate - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases Lactate - 2.5 hours after normothermic machine perfusion |
Bile gas Lactate - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases Glucose - 4 hours after normothermic machine perfusion |
Bile gas Glucose - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases Glucose - 2.5 hours after normothermic machine perfusion |
Bile gas Glucose - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases Oxygen (O2) - 4 hours after normothermic machine perfusion |
Bile gas O2 - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases O2 - 2.5 hours after normothermic machine perfusion |
Bile gas O2 - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases carbon dioxide (CO2) - 4 hours after normothermic machine perfusion |
Bile gas CO2 - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases CO2 - 2.5 hours after normothermic machine perfusion |
Bile gas CO2 - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases bicarbonate (HCO3) - 4 hours after normothermic machine perfusion |
Bile gas HCO3 - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases HCO3 - 2.5 hours after normothermic machine perfusion |
Bile gas HCO3 - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases base excess (BE) - 4 hours after normothermic machine perfusion |
Bile gas BE - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Ischemia/reperfusion injury - 4 hours after normothermic machine perfusion |
Ischemia/reperfusion injury in liver biopsies, graded according to Ali JM et al, Liver transplant 2015; nil, mild, moderate, and severe. - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Ischemia/reperfusion damage - 4 hours after normothermic machine perfusion |
Ischemia/reperfusion damage in liver biopsies, graded according to Suzuki score (Tian Y et al, Stem Cell Research & Therapy, 2016); score 0, 1, 2, 3, (0=none, 4= severe) - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Ischemia/reperfusion injury - after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Ischemia/reperfusion injury in liver biopsies, graded according to Tian Y et al et al, Liver transplant 2015; nil, mild, moderate, and severe. - after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Ischemia/reperfusion damage - after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Ischemia/reperfusion damage in liver biopsies, graded according to Suzuki score (Tian Y et al, Stem Cell Research & Therapy, 2016); score 0, 1, 2, 3, (0=none, 4= severe) - after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Ischemia/reperfusion injury - before machine perfusion |
Ischemia/reperfusion injury in liver biopsies, graded according to Ali JM et al, Liver transplant 2015; nil, mild, moderate, and severe. - before machine perfusion in extended criteria donors livers |
1 minute |
|
Secondary |
Ischemia/reperfusion damage - before machine perfusion |
Ischemia/reperfusion damage in liver biopsies, graded according to Suzuki score (Tian Y et al, Stem Cell Research & Therapy, 2016); score 0, 1, 2, 3, (0=none, 4= severe) - before machine perfusion in extended criteria donors livers |
1 minute |
|
Secondary |
Ischemia/reperfusion injury - after controlled oxygenated rewarming machine perfusion - 1 hour |
Ischemia/reperfusion injury in liver biopsies, graded according to Ali JM et al, Liver transplant 2015; nil, mild, moderate, and severe - after controlled oxygenated rewarming machine perfusion - 1 hour in extended criteria donors livers |
1 hour |
|
Secondary |
Ischemia/reperfusion damage - after controlled oxygenated rewarming machine perfusion - 1 hour |
Ischemia/reperfusion damage in liver biopsies, graded according to Suzuki score (Tian Y et al, Stem Cell Research & Therapy, 2016); score 0, 1, 2, 3, (0=none, 4= severe) - after controlled oxygenated rewarming machine perfusion - 1 hour in extended criteria donors livers |
1 hour |
|
Secondary |
Ischemia/reperfusion injury - 2.5 hours after normothermic machine perfusion |
Ischemia/reperfusion injury in liver biopsies, graded according to Ali JM et al, Liver transplant 2015; nil, mild, moderate, and severe. - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Ischemia/reperfusion damage - 2.5 hours after normothermic machine perfusion |
Ischemia/reperfusion damage in liver biopsies, graded according to Suzuki score (Tian Y et al, Stem Cell Research & Therapy, 2016); score 0, 1, 2, 3, (0=none, 4= severe) - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases BE - 2.5 hours after normothermic machine perfusion |
Bile gas BE - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases oxygen saturation (SO2) - 4 hours after normothermic machine perfusion |
Bile gas SO2- 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases SO2 - 2.5 hours after normothermic machine perfusion |
Bile gas SO2- 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases hemoglobin (Hb)- 4 hours after normothermic machine perfusion |
Bile gas Hb - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases Hb - 2.5 hours after normothermic machine perfusion |
Bile gas Hb - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases sodium (Na) - 4 hours after normothermic machine perfusion |
Bile gas Na - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases Na - 2.5 hours after normothermic machine perfusion |
Bile gas Na - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases potassium (K) - 4 hours after normothermic machine perfusion |
Bile gas K - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases K - 2.5 hours after normothermic machine perfusion |
Bile gas K - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gases Calcium (Ca) - 4 hours after normothermic machine perfusion |
Bile gas Ca - 4 hours after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Bile gases Ca - 2.5 hours after normothermic machine perfusion |
Bile gas Ca - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Markers of injury, inflammation - 2.5 hours after normothermic machine perfusion |
Markers of injury, inflammation - 2.5 hours after normothermic machine perfusion in extended criteria donors livers. |
2.5 hours |
|
Secondary |
Bile gas lactate 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas lactate 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Markers of injury, inflammation 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Markers of injury, inflammation 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas Glucose 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas Glucose 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas pH 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas pH 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas O2 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas O2 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas CO2 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas CO2 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas HCO3 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas HCO3 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas SO2 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas SO2 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas Hemoglobin 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas Hemoglobin 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas Na 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas Na 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas K 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas K 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas Ca 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas Ca 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Bile gas BE 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion |
Bile gas BE 2 hours after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Markers of injury, inflammation 1 hour after controlled oxygenated rewarming machine perfusion |
Markers of injury, inflammation 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hour |
|
Secondary |
Bile gas lactate 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas lactate 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas Glucose 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas Glucose 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas pH 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas pH 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Markers of injury, inflammation 1 hour after controlled oxygenated rewarming machine perfusion |
Markers of injury, inflammation 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas O2 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas O2 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas CO2 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas CO2 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas HCO3 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas HCO3 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas BE 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas BE 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas SO2 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas SO2 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas hemoglobin 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas hemoglobin 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas Na 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas Na 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas K 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas K 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Bile gas Ca 1 hour after controlled oxygenated rewarming machine perfusion |
Bile gas Ca 1 hour after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hours |
|
Secondary |
Perfusate gas Ca - during machine perfusion |
Perfusate gas Ca during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas pH - during machine perfusion |
Perfusate gas pH during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas SO2 - during machine perfusion |
Perfusate gas SO2 during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas O2 - during machine perfusion |
Perfusate gas O2 during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas CO2 - during machine perfusion |
Perfusate gas CO2 during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas K - during machine perfusion |
Perfusate gas K during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas Na - during machine perfusion |
Perfusate gas Na during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas BE - during machine perfusion |
Perfusate gas BE during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas HCO3 - during machine perfusion |
Perfusate gas HCO3 during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas hemoglobin - during machine perfusion |
Perfusate gas hemoglobin during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas lactate - during machine perfusion |
Perfusate gas lactate during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Perfusate gas glucose - during machine perfusion |
Perfusate gas glucose during machine perfusion in extended criteria donors livers. |
24 hours |
|
Secondary |
Postoperative complications |
According to Clavien Dindo Classification |
12 months |
|
Secondary |
Length of stay |
Length of initial ICU and initial hospital stay is determined in days of admission following liver transplantation. |
4 months |
|
Secondary |
Machine flow during controlled oxygenated rewarming |
Machine flow (millilitre/hour) |
1 hour |
|
Secondary |
Machine flow during Dual-end-ischemic Hypothermic Oxygenated Perfusion |
Machine flow (millilitre/hour) |
1 hour |
|
Secondary |
Machine pressure during controlled oxygenated rewarming |
Machine pressure ((millimetre Hg)) |
1 hour |
|
Secondary |
Machine pressure during Dual-end-ischemic Hypothermic Oxygenated Perfusion |
Machine pressure ((millimetre Hg)) |
1 hour |
|
Secondary |
Machine Fraction of oxygen during controlled oxygenated rewarming |
Machine fraction of oxygen (%) |
1 hour |
|
Secondary |
Machine Fraction of oxygen Dual-end-ischemic Hypothermic Oxygenated Perfusion |
Machine fraction of oxygen (%) |
1 hour |
|
Secondary |
Machine Resistance during controlled oxygenated rewarming |
Machine Resistance (millilitre/minute/millimetre Hg) |
1 hour |
|
Secondary |
Machine Resistance during Dual-end-ischemic Hypothermic Oxygenated Perfusion |
Machine Resistance (millilitre/minute/millimetre Hg) |
1 hour |
|
Secondary |
Machine flow during Dual-end-ischemic Hypothermic Oxygenated Perfusion |
Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion flow (millilitre/hour) |
2 hours |
|
Secondary |
Machine flow during normothermic machine perfusion |
Machine flow during normothermic machine perfusion (millilitre/hour) |
4 hours |
|
Secondary |
Machine flow during normothermic machine perfusion |
Machine flow during normothermic machine perfusion (millilitre/hour) |
2.5 hours |
|
Secondary |
Machine pressure during normothermic machine perfusion |
Machine pressure (millimetre Hg) |
4 hours |
|
Secondary |
Machine pressure during normothermic machine perfusion |
Machine pressure (millimetre Hg) |
2.5 hours |
|
Secondary |
Machine Fraction of oxygen during normothermic machine perfusion |
Machine fraction of oxygen (%) |
4 hours |
|
Secondary |
Machine Fraction of oxygen during normothermic machine perfusion |
Machine fraction of oxygen (%) |
2.5 hours |
|
Secondary |
Machine Resistance during normothermic machine perfusion |
Machine Resistance (millilitre/minute/millimetre Hg) |
4 hours |
|
Secondary |
Machine Resistance during normothermic machine perfusion |
Machine Resistance (millilitre/minute/millimetre Hg) |
2.5 hours |
|
Secondary |
Total preservation time |
Total preservation time (machine perfusion time) |
48 hours |
|
Secondary |
Alanine amino transferase in perfusate during machine perfusion |
Alanine amino transferase in perfusate during machine perfusion (U/Litre) |
24 hours |
|
Secondary |
Aspartate amino transferase in perfusate during machine perfusion |
Aspartate amino transferase in perfusate during machine perfusion (U/Litre) |
24 hours |
|
Secondary |
Alkaline phosphatase in perfusate during machine perfusion |
Aspartate amino transferase in perfusate during machine perfusion (U/Litre) |
24 hours |
|
Secondary |
Gamma-glutamyl transferase in perfusate during machine perfusion |
Gamma-glutamyl transferase in perfusate during machine perfusion (U/Litre) |
24 hours |
|
Secondary |
Urea in perfusate during machine perfusion |
Urea in perfusate during machine perfusion (millimol/Litre) |
24 hours |
|
Secondary |
Bilirubin in perfusate during machine perfusion |
Bilirubin in perfusate during machine perfusion (micromol/Litre) |
24 hours |
|
Secondary |
Not yet decided types of cytokines/interleukins, endothelium markers, miRNA's in perfusate during machine perfusion |
Different cytokines/interleukins, endothelium markers, miRNA's in perfusate during machine perfusion |
24 hours |
|
Secondary |
Not yet decided types of cytokines/interleukins, endothelium markers, miRNA's in liver tissue during machine perfusion |
Different cytokines/interleukins, endothelium markers, miRNA's in liver tissue during machine perfusion |
24 hours |
|
Secondary |
Not yet decided types of cytokines/interleukins, endothelium markers, miRNA's in bile during machine perfusion |
Different cytokines/interleukins, endothelium markers, miRNA's in bile during machine perfusion |
24 hours |
|
Secondary |
Histopathology - liver tissue. Mitochondrial function |
Histological analysis of parenchymal biopsies which are assessed for mitochondrial function. |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - bile duct. Mitochondrial function |
Histological analysis of bile duct biopsies which are assessed for mitochondrial function. |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - liver tissue. Perfusion/reperfusion injury |
Histological analysis of parenchymal biopsies which are assessed for perfusion/reperfusion injury |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - bile duct. Perfusion/reperfusion injury |
Histological analysis of bile duct biopsies which are assessed for perfusion/reperfusion injury |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - liver tissue. Cell death |
Histological analysis of parenchymal biopsies which are assessed for cell death |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - bile duct. Cell death |
Histological analysis of bile duct biopsies which are assessed for cell death |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - liver tissue. Inflammation |
Histological analysis of parenchymal biopsies which are assessed for inflammation |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - bile duct. Inflammation |
Histological analysis of bile duct biopsies which are assessed for inflammation |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - liver tissue. Metabolomics |
Histological analysis of parenchymal biopsies which are assessed for metabolomics |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - bileduct. Metabolomics |
Histological analysis of bile duct biopsies which are assessed for metabolomics |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - liver tissue. Lipidomics |
Histological analysis of parenchymal biopsies which are assessed for lipidomics |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - bile duct. Lipidomics |
Histological analysis of bile duct biopsies which are assessed for lipidomics |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - liver tissue. RNA sequencing |
Histological analysis of parenchymal biopsies which are assessed for RNA sequencing |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - bile duct. RNA sequencing |
Histological analysis of bile duct biopsies which are assessed for RNA sequencing |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - liver tissue. Endothelium properties |
Histological analysis of parenchymal biopsies which are assessed for endothelium properties |
During machine perfusion - 24 hours |
|
Secondary |
Histopathology - bile duct. Endothelium properties |
Histological analysis of bile duct biopsies which are assessed for endothelium properties |
During machine perfusion - 24 hours |
|
Secondary |
International normalized ratio on postoperative day 7 |
Blood sample from recipient: International normalized ratio on postoperative day 7 |
7 postoperative day |
|
Secondary |
Alanine amino transferase postoperative day 0 |
Alanine amino transferase postoperative day 0 in the donated recipients (U/Litre) |
Postoperative day 0 |
|
Secondary |
Aspartate amino transferase postoperative day 0 |
Aspartate amino transferase postoperative day 0 in the donated recipients (U/Litre) |
Postoperative day 0 |
|
Secondary |
Alkaline phosphatase postoperative day 0 |
Alkaline phosphatase postoperative day 0 in the donated recipients (U/Litre) |
Postoperative day 0 |
|
Secondary |
Gamma-glutamyl transferase postoperative day 0 |
Gamma-glutamyl transferase postoperative day 0 in the donated recipients (U/Litre) |
Postoperative day 0 |
|
Secondary |
Urea postoperative day 0 |
Urea postoperative day 0 in the donated recipients (millimol/Litre) |
Postoperative day 0 |
|
Secondary |
Bilirubin postoperative day 0 |
Bilirubin postoperative day 0 in the donated recipients (micromol/Litre) |
Postoperative day 0 |
|
Secondary |
Bilirubin postoperative day 1 |
Bilirubin postoperative day 1 in the donated recipients (micromol/Litre) |
Postoperative day 1 |
|
Secondary |
Bilirubin postoperative day 2 |
Bilirubin postoperative day 2 in the donated recipients (micromol/Litre) |
Postoperative day 2 |
|
Secondary |
Bilirubin postoperative day 3 |
Bilirubin postoperative day 3 in the donated recipients (micromol/Litre) |
Postoperative day 3 |
|
Secondary |
Bilirubin postoperative day 4 |
Bilirubin postoperative day 4 in the donated recipients (micromol/Litre) |
Postoperative day 4 |
|
Secondary |
Bilirubin postoperative day 5 |
Bilirubin postoperative day 5 in the donated recipients (micromol/Litre) |
Postoperative day 5 |
|
Secondary |
Bilirubin postoperative day 6 |
Bilirubin postoperative day 6 in the donated recipients (micromol/Litre) |
Postoperative day 6 |
|
Secondary |
Bilirubin postoperative day 7 |
Bilirubin postoperative day 7 in the donated recipients (micromol/Litre) |
Postoperative day 7 |
|
Secondary |
Urea postoperative day 1 |
Urea postoperative day 1 in the donated recipients (millimol/Litre) |
Postoperative day 1 |
|
Secondary |
Urea postoperative day 2 |
Urea postoperative day 2 in the donated recipients (millimol/Litre) |
Postoperative day 2 |
|
Secondary |
Urea postoperative day 3 |
Urea postoperative day 3 in the donated recipients (millimol/Litre) |
Postoperative day 3 |
|
Secondary |
Urea postoperative day 4 |
Urea postoperative day 4 in the donated recipients (millimol/Litre) |
Postoperative day 4 |
|
Secondary |
Urea postoperative day 5 |
Urea postoperative day 5 in the donated recipients (millimol/Litre) |
Postoperative day 5 |
|
Secondary |
Urea postoperative day 6 |
Urea postoperative day 6 in the donated recipients (millimol/Litre) |
Postoperative day 6 |
|
Secondary |
Urea postoperative day 7 |
Urea postoperative day 7 in the donated recipients (millimol/Litre) |
Postoperative day 7 |
|
Secondary |
Aspartate amino transferase postoperative day 1 |
Aspartate amino transferase postoperative day 1 in the donated recipients (U/Litre) |
Postoperative day 1 |
|
Secondary |
Alkaline phosphatase postoperative day 1 |
Alkaline phosphatase postoperative day 1 in the donated recipients (U/Litre) |
Postoperative day 1 |
|
Secondary |
Gamma-glutamyl transferase postoperative day 1 |
Gamma-glutamyl transferase postoperative day 1 in the donated recipients (U/Litre) |
Postoperative day 1 |
|
Secondary |
Alanine amino transferase postoperative day 2 |
Alanine amino transferase postoperative day 2 in the donated recipients (U/Litre) |
Postoperative day 2 |
|
Secondary |
Aspartate amino transferase postoperative day 2 |
Aspartate amino transferase postoperative day 2 in the donated recipients (U/Litre) |
Postoperative day 2 |
|
Secondary |
Alkaline phosphatase postoperative day 2 |
Alkaline phosphatase postoperative day 2 in the donated recipients (U/Litre) |
Postoperative day 2 |
|
Secondary |
Gamma-glutamyl transferase postoperative day 2 |
Gamma-glutamyl transferase postoperative day 2 in the donated recipients (U/Litre) |
Postoperative day 2 |
|
Secondary |
Alanine amino transferase postoperative day 3 |
Alanine amino transferase postoperative day 3 in the donated recipients (U/Litre) |
Postoperative day 3 |
|
Secondary |
Aspartate amino transferase postoperative day 3 |
Aspartate amino transferase postoperative day 3 in the donated recipients (U/Litre) |
Postoperative day 3 |
|
Secondary |
Alkaline phosphatase postoperative day 3 |
Alkaline phosphatase postoperative day 3 in the donated recipients (U/Litre) |
Postoperative day 3 |
|
Secondary |
Gamma-glutamyl transferase postoperative day 3 |
Gamma-glutamyl transferase postoperative day 3 in the donated recipients (U/Litre) |
Postoperative day 3 |
|
Secondary |
Alanine amino transferase postoperative day 4 |
Alanine amino transferase postoperative day 4 in the donated recipients (U/Litre) |
Postoperative day 4 |
|
Secondary |
Aspartate amino transferase postoperative day 4 |
Aspartate amino transferase postoperative day 4 in the donated recipients (U/Litre) |
Postoperative day 4 |
|
Secondary |
Alkaline phosphatase postoperative day 4 |
Alkaline phosphatase postoperative day 4 in the donated recipients (U/Litre) |
Postoperative day 4 |
|
Secondary |
Gamma-glutamyl transferase postoperative day 4 |
Gamma-glutamyl transferase postoperative day 4 in the donated recipients (U/Litre) |
Postoperative day 4 |
|
Secondary |
Alanine amino transferase postoperative day 5 |
Alanine amino transferase postoperative day 5 in the donated recipients (U/Litre) |
Postoperative day 5 |
|
Secondary |
Aspartate amino transferase postoperative day 5 |
Aspartate amino transferase postoperative day 5 in the donated recipients (U/Litre) |
Postoperative day 5 |
|
Secondary |
Alkaline phosphatase postoperative day 5 |
Alkaline phosphatase postoperative day 5 in the donated recipients (U/Litre) |
Postoperative day 5 |
|
Secondary |
Gamma-glutamyl transferase postoperative day 5 |
Gamma-glutamyl transferase postoperative day 5 in the donated recipients (U/Litre) |
Postoperative day 5 |
|
Secondary |
Alanine amino transferase postoperative day 6 |
Alanine amino transferase postoperative day 6 in the donated recipients (U/Litre) |
Postoperative day 6 |
|
Secondary |
Aspartate amino transferase postoperative day 6 |
Aspartate amino transferase postoperative day 6 in the donated recipients (U/Litre) |
Postoperative day 6 |
|
Secondary |
Alkaline phosphatase postoperative day 6 |
Aspartate amino transferase postoperative day 6 in the donated recipients (U/Litre) |
Postoperative day 6 |
|
Secondary |
Gamma-glutamyl transferase postoperative day 6 |
Gamma-glutamyl transferase postoperative day 6 in the donated recipients (U/Litre) |
Postoperative day 6 |
|
Secondary |
Alanine amino transferase postoperative day 7 |
Alanine amino transferase postoperative day 7 in the donated recipients (U/Litre) |
Postoperative day 7 |
|
Secondary |
Aspartate amino transferase postoperative day 7 |
Aspartate amino transferase postoperative day 7 in the donated recipients (U/Litre) |
Postoperative day 7 |
|
Secondary |
Alkaline phosphatase postoperative day 7 |
Alkaline phosphatase postoperative day 7 in the donated recipients (U/Litre) |
Postoperative day 7 |
|
Secondary |
Gamma-glutamyl transferase postoperative day 7 |
Gamma-glutamyl transferase postoperative day 7 in the donated recipients (U/Litre) |
Postoperative day 7 |
|
Secondary |
Alanine amino transferase postoperative month 1 |
Alanine amino transferase postoperative month 1 in the donated recipients (U/Litre) |
1 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 1 |
Aspartate amino transferase postoperative month 1 in the donated recipients (U/Litre) |
1 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 1 |
Alkaline phosphatase postoperative month 1 in the donated recipients (U/Litre) |
1 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 1 |
Gamma-glutamyl transferase postoperative month 1 in the donated recipients (U/Litre) |
1 month after surgery |
|
Secondary |
Urea postoperative month 1 |
Urea postoperative month 1 in the donated recipients (millimol/Litre) |
1 month after surgery |
|
Secondary |
Bilirubin postoperative month 1 |
Bilirubin postoperative month 1 in the donated recipients (micromol/Litre) |
1 month after surgery |
|
Secondary |
Bilirubin postoperative month 2 |
Bilirubin postoperative month 2 in the donated recipients (micromol/Litre) |
2 month after surgery |
|
Secondary |
Bilirubin postoperative month 3 |
Bilirubin postoperative month 3 in the donated recipients (micromol/Litre) |
3 month after surgery |
|
Secondary |
Bilirubin postoperative month 4 |
Bilirubin postoperative month 4 in the donated recipients (micromol/Litre) |
4 month after surgery |
|
Secondary |
Bilirubin postoperative month 5 |
Bilirubin postoperative month 5 in the donated recipients (micromol/Litre) |
5 month after surgery |
|
Secondary |
Bilirubin postoperative month 6 |
Bilirubin postoperative month 6 in the donated recipients (micromol/Litre) |
6 month after surgery |
|
Secondary |
Bilirubin postoperative month 7 |
Bilirubin postoperative month 7 in the donated recipients (micromol/Litre) |
7 month after surgery |
|
Secondary |
Bilirubin postoperative month 8 |
Bilirubin postoperative month 8 in the donated recipients (micromol/Litre) |
8 month after surgery |
|
Secondary |
Bilirubin postoperative month 9 |
Bilirubin postoperative month 9 in the donated recipients (micromol/Litre) |
9 month after surgery |
|
Secondary |
Bilirubin postoperative month 10 |
Bilirubin postoperative month 10 in the donated recipients (micromol/Litre) |
10 month after surgery |
|
Secondary |
Bilirubin postoperative month 11 |
Bilirubin postoperative month 11 in the donated recipients (micromol/Litre) |
11 month after surgery |
|
Secondary |
Bilirubin postoperative month 12 |
Bilirubin postoperative month 12 in the donated recipients (micromol/Litre) |
12 month after surgery |
|
Secondary |
Urea postoperative month 2 |
Urea postoperative month 2 in the donated recipients (millimol/Litre) |
2 month after surgery |
|
Secondary |
Urea postoperative month 3 |
Urea postoperative month 3 in the donated recipients (millimol/Litre) |
3 month after surgery |
|
Secondary |
Urea postoperative month 4 |
Urea postoperative month 4 in the donated recipients (millimol/Litre) |
4 month after surgery |
|
Secondary |
Urea postoperative month 5 |
Urea postoperative month 5 in the donated recipients (millimol/Litre) |
5 month after surgery |
|
Secondary |
Urea postoperative month 6 |
Urea postoperative month 6 in the donated recipients (millimol/Litre) |
6 month after surgery |
|
Secondary |
Urea postoperative month 7 |
Urea postoperative month 7 in the donated recipients (millimol/Litre) |
7 month after surgery |
|
Secondary |
Urea postoperative month 8 |
Urea postoperative month 8 in the donated recipients (millimol/Litre) |
8 month after surgery |
|
Secondary |
Urea postoperative month 9 |
Urea postoperative month 9 in the donated recipients (millimol/Litre) |
9 month after surgery |
|
Secondary |
Urea postoperative month 10 |
Urea postoperative month 10 in the donated recipients (millimol/Litre) |
10 month after surgery |
|
Secondary |
Urea postoperative month 11 |
Urea postoperative month 11 in the donated recipients (millimol/Litre) |
11 month after surgery |
|
Secondary |
Urea postoperative month 12 |
Urea postoperative month 12 in the donated recipients (millimol/Litre) |
12 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 2 |
Alanine amino transferase postoperative month 2 in the donated recipients (U/Litre) |
2 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 2 |
Aspartate amino transferase postoperative month 2 in the donated recipients (U/Litre) |
2 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 2 |
Alkaline phosphatase postoperative month 2 in the donated recipients (U/Litre) |
2 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 2 |
Gamma-glutamyl transferase postoperative month 2 in the donated recipients (U/Litre) |
2 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 3 |
Alanine amino transferase postoperative month 3 in the donated recipients (U/Litre) |
3 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 3 |
Aspartate amino transferase postoperative month 3 in the donated recipients (U/Litre) |
3 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 3 |
Alkaline phosphatase postoperative month 3 in the donated recipients (U/Litre) |
3 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 3 |
Gamma-glutamyl transferase postoperative month 3 in the donated recipients (U/Litre) |
3 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 4 |
Alanine amino transferase postoperative month 4 in the donated recipients (U/Litre) |
4 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 4 |
Aspartate amino transferase postoperative month 4 in the donated recipients (U/Litre) |
4 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 4 |
Alkaline phosphatase postoperative month 4 in the donated recipients (U/Litre) |
4 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 4 |
Gamma-glutamyl transferase postoperative month 4 in the donated recipients (U/Litre) |
4 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 5 |
Alanine amino transferase postoperative month 5 in the donated recipients (U/Litre) |
5 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 5 |
Aspartate amino transferase postoperative month 5 in the donated recipients (U/Litre) |
5 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 5 |
Alkaline phosphatase postoperative month 5 in the donated recipients (U/Litre) |
5 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 5 |
Gamma-glutamyl transferase postoperative month 5 in the donated recipients (U/Litre) |
5 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 6 |
Alanine amino transferase postoperative month 6 in the donated recipients (U/Litre) |
6 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 6 |
Aspartate amino transferase postoperative month 6 in the donated recipients (U/Litre) |
6 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 6 |
Alkaline phosphatase postoperative month 6 in the donated recipients (U/Litre) |
6 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 6 |
Gamma-glutamyl transferase postoperative month 6 in the donated recipients (U/Litre) |
6 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 7 |
Alanine amino transferase postoperative month 7 in the donated recipients (U/Litre) |
7 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 7 |
Aspartate amino transferase postoperative month 7 in the donated recipients (U/Litre) |
7 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 7 |
Alkaline phosphatase postoperative month 7 in the donated recipients (U/Litre) |
7 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 7 |
Gamma-glutamyl transferase postoperative month 7 in the donated recipients (U/Litre) |
7 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 8 |
Alanine amino transferase postoperative month 8 in the donated recipients (U/Litre) |
8 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 8 |
Aspartate amino transferase postoperative month 8 in the donated recipients (U/Litre) |
8 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 8 |
Alkaline phosphatase postoperative month 8 in the donated recipients (U/Litre) |
8 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 8 |
Gamma-glutamyl transferase postoperative month 8 in the donated recipients (U/Litre) |
8 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 9 |
Alanine amino transferase postoperative month 9 in the donated recipients (U/Litre) |
9 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 9 |
Aspartate amino transferase postoperative month 9 in the donated recipients (U/Litre) |
9 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 9 |
Alkaline phosphatase postoperative month 9 in the donated recipients (U/Litre) |
9 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 9 |
Gamma-glutamyl transferase postoperative month 9 in the donated recipients (U/Litre) |
9 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 10 |
Alanine amino transferase postoperative month 10 in the donated recipients (U/Litre) |
10 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 10 |
Aspartate amino transferase postoperative month 10 in the donated recipients (U/Litre) |
10 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 10 |
Alkaline phosphatase postoperative month 10 in the donated recipients (U/Litre) |
10 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 10 |
Gamma-glutamyl transferase postoperative month 10 in the donated recipients (U/Litre) |
10 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 11 |
Alanine amino transferase postoperative month 11 in the donated recipients (U/Litre) |
11 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 11 |
Aspartate amino transferase postoperative month 11 in the donated recipients (U/Litre) |
11 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 11 |
Alkaline phosphatase postoperative month 11 in the donated recipients (U/Litre) |
11 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 11 |
Gamma-glutamyl transferase postoperative month 11 in the donated recipients (U/Litre) |
11 month after surgery |
|
Secondary |
Alanine amino transferase postoperative month 12 |
Alanine amino transferase postoperative month 12 in the donated recipients (U/Litre) |
12 month after surgery |
|
Secondary |
Aspartate amino transferase postoperative month 12 |
Aspartate amino transferase postoperative month 12 in the donated recipients (U/Litre) |
12 month after surgery |
|
Secondary |
Alkaline phosphatase postoperative month 12 |
Alkaline phosphatase postoperative month 12 in the donated recipients (U/Litre) |
12 month after surgery |
|
Secondary |
Gamma-glutamyl transferase postoperative month 12 |
Gamma-glutamyl transferase postoperative month 12 in the donated recipients (U/Litre) |
12 month after surgery |
|
Secondary |
Postoperative microdialysis levels of lactate |
Postoperative microdialysis levels of lactate in transplanted livers the first 14 postoperative days |
14 days |
|
Secondary |
Postoperative microdialysis levels of pyruvate |
Postoperative microdialysis levels of pyruvate in transplanted livers the first 14 postoperative days |
14 days |
|
Secondary |
Postoperative microdialysis levels of glycerol |
Postoperative microdialysis levels of glycerol in transplanted livers the first 14 postoperative days |
14 days |
|
Secondary |
Postoperative microdialysis levels of glucose |
Postoperative microdialysis levels of glucose in transplanted livers the first 14 postoperative days |
14 days |
|
Secondary |
Systolic blood pressure |
Systolic blood pressure (millimeter Hg) |
From 5 min before reperfusion, up to 20 minutes after reperfusion |
|
Secondary |
Diastolic blood pressure |
Diastolic blood pressure (millimeter Hg) |
From 5 min before reperfusion, up to 20 minutes after reperfusion |
|
Secondary |
Heart rate |
Heart rate (Beats/minute) |
From 5 min before reperfusion, up to 20 minutes after reperfusion |
|
Secondary |
Vasopressor dosage |
Vasopressor dosage (microgram/kilogram/minutes) |
From 5 min before reperfusion, up to 20 minutes after reperfusion |
|
Secondary |
Patient survival |
Patient survival (days) |
Through study completion, an average of 12 months |
|
Secondary |
Graft survival |
Graft (censored and uncensored for patient death) survival (days) |
Through study completion, an average of 12 months |
|
Secondary |
Number of deaths |
Number of deaths first 7 days after transplantation |
7 days after transplantation |
|
Secondary |
Number of retransplantation |
Number of retransplantation first 7 days after transplantation |
7 days after transplantation |
|
Secondary |
Incidens of new onset diabetes after transplantation |
New onset diabetes after transplantation after transplantation. New onset diabetes after transplantation is defined according to the World Health Organization criteria (Report 2003 S5-20). |
Through study completion, an average of 12 months |
|
Secondary |
Estimated glomerular filtration rate - Renal function |
Estimated glomerular filtration rate according to the 4-variable Modification of Diet in Renal Disease equation. |
Through study completion, an average of 12 months |
|
Secondary |
The incidence of symptomatic Non-anastomotic Biliary Strictures |
The incidence of symptomatic non-anastomotic biliary strictures |
6 months |
|
Secondary |
The incidence of asymptomatic Non-anastomotic Biliary Strictures |
The incidence of asymptomatic non-anastomotic biliary strictures |
6 months |
|
Secondary |
The incidence of asymptomatic Non-anastomotic Biliary Strictures |
The incidence of asymptomatic non-anastomotic biliary strictures |
12 months |
|
Secondary |
The incidence of symptomatic Non-anastomotic Biliary Strictures |
The incidence of symptomatic non-anastomotic biliary strictures |
12 months |
|
Secondary |
The severity of Non-anastomotic Biliary Strictures |
The severity of Non-anastomotic Biliary Strictures based on a scoring system described by Buis et. al (mild, moderate, or severe) |
Through study completion, an average of 12 months |
|
Secondary |
The location of Non-anastomotic Biliary Strictures |
The location of Non-anastomotic Biliary Strictures is assessed by images of the magnetic resonance cholangiopancreatography |
Through study completion, an average of 12 months |
|
Secondary |
The incidence of infections |
The incidence of infections leading to administration of antibiotics/antifungal/antiviral treatment |
Through study completion, an average of 12 months |
|
Secondary |
Lactate level in microdialysate from liver tissue - 4 hours |
Microdialysis lactate level in donor liver tissue after 4 hours of normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Pyruvate level in microdialysate from hilar plate after normothermic machine perfusion - 4 hours |
Pyruvate level in microdialysate from hilar plate after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Glycerol level in microdialysate from hilar plate after normothermic machine perfusion - 4 hours |
Glycerol level in microdialysate from hilar plate after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Glucose level in microdialysate from hilar plate after normothermic machine perfusion - 4 hours |
Glucose level in microdialysate from hilar plate after normothermic machine perfusion in extended criteria donors livers. |
4 hours |
|
Secondary |
Glycerol level in microdialysate from hilar plate after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Glycerol level in microdialysate from hilar plate after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Lactate level in microdialysate from hilar plate after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion - 2 hours |
Lactate level in microdialysate from hilar plate after Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hours |
|
Secondary |
Glucose level in microdialysate from hilar plate after controlled oxygenated rewarming machine perfusion - 1 hour |
Glucose level in microdialysate from hilar plate after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hour |
|
Secondary |
Pyruvate level in microdialysate from hilar plate after controlled oxygenated rewarming machine perfusion - 1 hour |
Pyruvate level in microdialysate from hilar plate after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hour |
|
Secondary |
Glycerol level in microdialysate from hilar plate after controlled oxygenated rewarming machine perfusion - 1 hour |
Glycerol level in microdialysate from hilar plate after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hour |
|
Secondary |
Lactate level in microdialysate from hilar plate after controlled oxygenated rewarming machine perfusion - 1 hour |
Lactate level in microdialysate from hilar plate after controlled oxygenated rewarming machine perfusion in extended criteria donors livers. |
1 hour |
|
Secondary |
Glucose level in microdialysate from hilar plate after of Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers - 2 hours |
Glucose level in microdialysate from hilar plate after of Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hour |
|
Secondary |
Pyruvate level in microdialysate from hilar plate after of Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers - 2 hours |
Pyruvate level in microdialysate from hilar plate after of Dual-end-ischemic Hypothermic Oxygenated Perfusion machine perfusion in extended criteria donors livers. |
2 hour |
|