[18F]FAPI PET/CT in Suspicious Focal Liver Lesions Without FDG Avidity

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

Fibroblast activation protein (FAP) is a serine protease that belongs to the dipeptidyl peptidase-IV (DPP-IV) family located in fbroblast membranes. FAP is overexpressed in the cancer-associated fbroblasts (CAFs) of 90% of epithelial carcinomas, including primary and metastatic liver cancer. Therefore, FAP-targeted radiopharmaceuticals can be considered a promising approach for visualizing CAFs. CAFs are crucial components of the tumor stroma, promote the growth of cancer cells, and are associated with poor prognosis. Currently, 18F-labelled fbroblast activation protein inhibitor 18F-FAPI has shown promising diagnostic value in many types of tumors, especially those in which are not avid for 18F-FDF , and several studies have demonstrated that 18F-FAPI PET/CT is superior to 18F-FDG PET/CT for detecting liver cancer and has lower tracer uptake in normal liver tissue. We aim to conduct a prospective study to investigate the diagnostic performance of 18F-FAPI PET/CT in evaluating suspicious liver mass without FDG avidity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05806333
Study type	Interventional
Source	Jilin University
Contact	Shi Gao [gshi]
Phone	+86-84995467
Email	Gaoshi@jlu.edu.cn
Status	Recruiting
Phase	N/A
Start date	June 1, 2022
Completion date	June 1, 2023

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