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NCT05767697 Clinical Trial

Genomics and Prognosis in GI Cancers

Liver Cancer Clinical Trial

Official title:
Explore the Correlation of Genomics and Prognosis in Alimentary Tract Cancers

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05767697
Other study ID # A-ER-109-073
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date April 15, 2020
Est. completion date December 31, 2025

Study information
Verified date March 2024
Source National Health Research Institutes, Taiwan
Contact Yung-Yeh Su, MD
Phone +886-6-7000123
Email yysu@nhri.edu.tw
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

This study aims to collect biospecimens and explore the correlation of genomics and prognosis in alimentary tract cancers.

Description:

In this study, the investigators will collect clinical specimens of alimentary tract cancers and perform DNA and RNA analysis to identify genetic alterations for the development of a comprehensive somatic mutation databases and investigate their potential correlation with clinical, radiological and pathological variables. The genomics study included but not limited to target gene panel sequencing, whole exome sequencing, whole genome sequencing, bulk RNA sequencing, single cell RNA sequencing and metagenomics.

Recruitment information / eligibility
Status Recruiting
Enrollment 1000
Est. completion date December 31, 2025
Est. primary completion date December 31, 2024
Accepts healthy volunteers
Gender All
Age group 20 Years and older
Eligibility Inclusion Criteria: - Able to sign the informed consent - Age >= 20 - Histology proved pancreatic cancer, esophageal cancer, gastric cancer, hepatocellular carcinoma, cholangiocarcinoma, colorectal cancer - Agree to provide tumor/normal tissue including but not limited to surgical specimen, biopsy, cytology specimen, bile, urine or stool - Agree to receive blood sampling 20ml at first time and 10ml during each follow-up (total sampling amount no more than 30ml per month) Exclusion Criteria: - Cannot cooperate with blood sampling

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan National Cheng-Kung University Hospital Tainan
Taiwan National Institute of Cancer Research Tainan

Sponsors (2)
Lead Sponsor Collaborator
National Health Research Institutes, Taiwan National Cheng-Kung University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of subjects who still survive at 1 year 1 year overall survival rate 1 year
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