Liver Cancer Clinical Trial
Official title:
Celebrex and Metformin for Postoperative Hepatocellular Carcinoma
This prospective trial aims to compare the role of celebrex alone, metformin alone, and celebrex plus metformin in preventing HCC recurrence after hepatic resection.
Hepatic resection is a popular curative treatment for patients with early-stage HCC and
well-preserved liver function. Although overall survival after resection has been increasing,
the median 5-year disease-free survival rate after resection remains at only about 37% for
early-stage HCC. In fact, the 5-year recurrence rate is as high as 74% for intermediate and
advanced HCC. Postoperative recurrence may be due to intrahepatic metastasis arising from the
primary tumor or it may be de novo metastasis (multicentric) that arises spontaneously in the
residual liver. Intrahepatic metastasis is the primary mechanism of early recurrence, which
occurs <2 years after resection; multicentric metastasis is the principal mechanism behind
late recurrence, which occurs at least 2 years after resection.
In the past few years, some observational studies with small sample size found metformin and
celebrex (selective cyclic oxidase-2 inhibitors) may reduce the rate of HCC after surgery.
However, no prospective study compare their efficacy in preventing HCC recurrence. This trial
aims to compare the role of celebrex alone, metformin alone, and celebrex plus metformin in
preventing HCC recurrence after hepatic resection.
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