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Association Between Autologous Transfusion and Recurrence-free Survival in Patients With HCC After Resection — AT/HCC  

Liver Cancer Clinical Trial

Official title:
Association Between Autologous Transfusion and Recurrence-free Survival in Patients With Hepatocellular Carcinoma After Resection-a Prospective Non-randomized Controlled Trial

Clinical Trial Summary

This prospective non-randomized controlled trial aims to determine whether autotransfusion of red blood cells salvaged before liver resection is associated with the recurrence-free survival in patients with hepatocellular carcinoma.

Clinical Trial Description

Preoperative and intraoperative blood salvage autotransfusion is used in various surgical procedures. However, because of the risk of reinfusion of salvaged blood contaminated by tumor cells, the use of autotransfusion in hepatocellular carcinoma (HCC) patients undergoing liver resection is controversial. The critical points include whether tumor cells can be cleared by autotransfusion, whether autotransfusion increases the risk of recurrence or metastasis, and what are the indications for autotransfusion. Moreover, some other issues are still not addressed. For example, is it warranted to take the risk of tumor dissemination by using autotransfusion to avoid allogeneic blood transfusion? Do the remaining tumor cells after additional filtration by leukocyte depletion filters still possess potential tumorigenicity? ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02654028
Study type Interventional
Source Guangxi Medical University
Contact
Status Completed
Phase N/A
Start date January 5, 2019
Completion date December 30, 2021
View Details
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