Liver Cancer Clinical Trial
Official title:
The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis in Cirrhotic Patients Infected With Chronic Hepatitis C Virus
Previous data have suggested that vitamin D levels may influence cancer development. In
particular, several single nucleotide polymorphisms have been described in the Vitamin D
receptor( VDR gene), and some polymorphisms are associated with tumor occurrence. For
instance, VDR polymorphisms have been related to cancers of the breast, prostate, skin,
colon-rectum, bladder and kidney, although with conflicting observations . VDR polymorphisms
have also been investigated in the context of some chronic liver diseases, such as chronic
hepatitis B, primary biliary cirrhosis and autoimmune hepatitis . In a recent published
study, VDR polymorphism may be used as a molecular marker to predict the risk and to evaluate
the disease severity of HCC in patients with chronic hepatitis B.
A significant association of VDR (ApaI) polymorphism with the development of HCC in chronic
HCV infection may help to identify those who are at high risk of developing HCC.
Hepatitis C virus (HCV) infection is one of the major public health problems worldwide .
Chronic HCV infection is characterized by a high rate of progression to fibrosis, chronic
hepatitis, leading to cirrhosis and ultimately to hepatocellular carcinoma (HCC). Early
detection is critically important because the most effective treatment for HCC is surgical
resection or ablation therapy when the tumour is small. On the other hand, genetic factors
can also contribute, particularly gene polymorphisms of inflammatory cytokines and growth
factor ligands and receptors . Vitamin D is involved in the metabolism of skeleton as a
systemic hormone but also has important roles in the regulation of host immune responses,
fibrogenesis and development of cancer through vitamin D receptor (VDR). Previous data have
suggested that vitamin D levels may influence cancer development. In particular, several
single nucleotide polymorphisms have been described in the VDR gene, and some polymorphisms
are associated with tumor occurrence. For instance, VDR polymorphisms have been related to
cancers of the breast, prostate, skin, colon-rectum, bladder and kidney, although with
conflicting observations. VDR polymorphisms have also been investigated in the context of
some chronic liver diseases, such as chronic hepatitis B, primary biliary cirrhosis and
autoimmune hepatitis . In a recent published study, VDR polymorphism may be used as a
molecular marker to predict the risk and to evaluate the disease severity of HCC in patients
with chronic hepatitis B.
A significant association of VDR ApaI polymorphism with the development of HCC in chronic HCV
infection may help to identify those who are at high risk of developing HCC.
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