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Lipid Metabolism Disorders clinical trials

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NCT ID: NCT02298322 Completed - Body Fat Disorder Clinical Trials

Subcutaneous Fat Reduction in the Submental Area

Start date: November 11, 2014
Phase: N/A
Study type: Interventional

Study to Evaluate Non-Invasive Subcutaneous Fat Reduction in the Submental Area using Cryolipolysis. Healthy adult men and women with submental skin fold thickness > 1cm who desire reduction of submental fat.

NCT ID: NCT02259153 Completed - Hyperlipidemias Clinical Trials

Effect of Different Fat Enriched Meats on the Hepatic Cholesterol Synthesis

Start date: March 2014
Phase: N/A
Study type: Interventional

The objective of the study is to assess the effect of two diets with different fat composition on cholesterol metabolism. The study was a randomized cross-over trial where volunteers follow two study periods with different types of meat (lean and fat red meat) separately by a ten days wash-out period. At the beginning of the study and after the study periods the following parameters are determined: anthropometric (weight, waist, circumference and body mass index), blood pressure, dietary (72-hours dietary registry) and exercise assessments and biochemical analysis (total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, apolipoprotein A1, apolipoprotein B, iron, transferring, ferritin, uric acid, glucose, HbA1c and insulin). Serum concentration of non cholesterol sterols (sitosterol, campesterol, stigmasterol, desmosterol and lanosterol) and oxysterols (24S-hydroxycholesterol, 27-hydroxycholesterol and 7α-hydroxycholestenone) were measured by High Performance Liquid Chromatography tandem Mass Spectrometry in these subjects throughout along the study in order to demonstrate the effect of different red meat on the hepatic metabolism of cholesterol.

NCT ID: NCT02243969 Completed - Hypertension Clinical Trials

Alpha-linolenic Acid and Blood Pressure

VASALA
Start date: May 2014
Phase: N/A
Study type: Interventional

Rationale: Increased intakes of n-3 long chain polyunsaturated fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), mainly found in fatty fish, are recommended for the prevention of coronary heart disease. Alpha-linolenic acid (ALA, C18:3n-3) is the most common vegetable-oil based n-3 fatty acid. Evidence exists that ALA supplementation can also have a protective effect on the development on cardiovascular disease, but may exert its cardio protective effects through different routes. The benefit may (partly) be due to blood pressure lowering. However, evidence for beneficial effects of ALA on blood pressure is conflicting. Therefore, we propose to investigate the effect of flaxseed oil, high in ALA, using a study powered on 24-hour blood pressure, in a population with high normal blood pressure and mild hypertension. Objective: To study the effects of flaxseed oil, rich in ALA on 24h-ambulatory mean arterial pressure (MAP) in men and women with high-normal blood pressure and mild hypertension compared to high oleic sunflower oil, poor in ALA. Study design: Using a double blind randomized, placebo-controlled parallel design, subjects will receive at random daily 10 g of flaxseed oil or a high-oleic acid sunflower oil (HOSF) as control for twelve weeks, with a run-in period of 14 days in advance. Study population: 72 men and women, aged 40-70 years, with untreated high-normal blood pressure and stage I hypertension and a body mass index between 25 and 35 kg/m2 will participate in the run-in and intervention period. It is estimated that 144 subject have to be screened to find 72 subjects that will enter the run-in period. Intervention: During the run-in period, subjects will receive daily 10 g of palm super olein oil. During the intervention period subjects receive either 10 g of HOSF or flaxseed oil. All oils are provided in bottles of 5 g, one will be consumed at breakfast or lunch and one at dinner. Main study parameters/endpoints: The main study parameter is the change in 24h-ambulatory mean arterial pressure (MAP)

NCT ID: NCT02081209 Completed - Body Fat Disorder Clinical Trials

Outer Thigh Study With Varied Treatment Parameters

Start date: February 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the performance of a cryolipolysis system using various treatment parameters for non-invasive reduction of subcutaneous fat in the lateral thighs.

NCT ID: NCT02081196 Completed - Body Fat Disorder Clinical Trials

CoolSculpting of the Flank With Alternate Treatment Parameters

Start date: February 18, 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of non-invasive subcutaneous fat layer reduction with an alternative treatment parameter.

NCT ID: NCT01968720 Completed - Dyslipidemias Clinical Trials

Pilot Study To Assess CAT-2003 in Patients With Severe Hypertriglyceridemia

Start date: October 2013
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the safety and efficacy of multiple doses of CAT-2003 in patients with severe hypertriglyceridemia either naive or refractory to current therapy. The study will evaluate effects of CAT-2003 on fasting and postprandial total triglycerides and chylomicron triglyceride levels in patients with severe hypertriglyceridemia. This is a single-blind study. All patients will receive placebo for a 14 day treatment period and CAT-2003 for a 28 day treatment period.

NCT ID: NCT01874132 Completed - Osteoporosis Clinical Trials

Study of the Long-term Effects of Exercise on Heath Indicators in Older People

Start date: May 2011
Phase: N/A
Study type: Interventional

Cardiovascular diseases (CVD) represent the most frequent cause of death among the elderly population. Hypertension, unfavorable lipid profile, obesity and physical inactivity are among the main risk factors for CVD. In contrast, mortality from CVD is inversely related to levels of physical activity, and is lower in individuals who exercise and have higher functional fitness levels. Thus, the Centers for Disease Control and Prevention, the American College of Sports Medicine, and the American Heart Association have recommended 20-30 min of moderate-to-vigorous aerobic training for the elderly, preferably every day or at least 3 days a week in the case of vigorous exercise.The same organizations also suggest the inclusion of resistance training in order to improve functional fitness. Therefore, the purpose of this study was to compare different exercise modalities in long-term changes of CVD risk factors and physical fitness among older adults.

NCT ID: NCT01859091 Completed - Body Fat Disorder Clinical Trials

Pilot Study on the Submental Area

Start date: October 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the safety and feasibility of cryolipolysis for non-invasive reduction of submental fat.

NCT ID: NCT01814007 Completed - Body Fat Disorder Clinical Trials

Multiple CoolSculpting Treatment Study

Start date: March 2013
Phase: N/A
Study type: Interventional

To evaluate the safety of same-day CoolSculpting treatments and to assess the impact on serum lipids and liver-related tests.

NCT ID: NCT01767142 Completed - Body Fat Disorder Clinical Trials

Feasibility Study of a Belt Applicator

Start date: January 2013
Phase: N/A
Study type: Interventional

Evaluate the safety and feasibility of non-invasive fat reduction in the outer thigh with a belt applicator. Applicator design and treatment parameters will be evaluated.