Linezolid Induced Thrombocytopenia Clinical Trial
Official title:
The Effect of N-acetylcysteine in Decreasing the Incidence of Linezolid-induced Thrombocytopenia in Critically Ill Patients
- Study the effect of acetylcysteine on decreasing the incidence of LIT in critically ill patients. - Study the impact of acetylcysteine on the time to onset of LIT and the time to recovery of platelets.
Primary outcome: difference in incidence of LIT between patients who received NAC and patients who didn't. - Primary outcome definition: Defined as platelets < 150000 OR decrease > 50% of baseline platelets. - Secondary outcome: difference in Time to onset of LIT and time to recovery between the 2 groups. - Secondary outcome definitions: after having thrombocytopenia, regardless of discontinuation of linezolid, recovery is defined as the restoration and maintenance of platelet counts > 70% of baseline values. ;