Clinical Trials Logo

Limb Deformities Congenital clinical trials

View clinical trials related to Limb Deformities Congenital.

Filter by:

NCT ID: NCT06455059 Enrolling by invitation - Hypochondroplasia Clinical Trials

Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia

Start date: June 1, 2024
Phase: Phase 3
Study type: Interventional

The intent and design of this Phase 3 study is to assess vosoritide as a therapeutic option for the treatment of children with hypochondroplasia (HCH).

NCT ID: NCT06410976 Recruiting - Hypochondroplasia Clinical Trials

Prospective Clinical Assessment Study in Children With Hypochondroplasia

HCH
Start date: June 5, 2024
Phase:
Study type: Observational

This is a long-term, multicenter, non-interventional study of children ages 2.5 to <17 years with hypochondroplasia (HCH).

NCT ID: NCT06212947 Recruiting - Hypochondroplasia Clinical Trials

A Multicenter Multinational Observational Study of Children With Hypochondroplasia

Start date: November 27, 2023
Phase:
Study type: Observational

This study will assess growth over time and the clinical course of HCH in children by collecting growth measurements and other variables of interest.

NCT ID: NCT05953857 Not yet recruiting - Penttinen Syndrome Clinical Trials

Knowing and Treating Kosaki/Penttinen Syndromes

IKKoPeS
Start date: October 2023
Phase:
Study type: Observational

Kosaki overgrowth syndrome (KOGS) and Penttinen syndrome (PS) are extremely rare multisystem disorders caused by heterozygous activating variants of the PDGFRB gene. KOGS results in characteristic craniofacial, orthopedic, skin and neurological disorders. PS is a progeroid disease responsible for a prematurely aged appearance. Patients suffer significant morbidity and mortality due to various complications. Tyrosine Kinase Inhibitors (TKIs) targeting PGDFRB appear to be a potential treatment option, as evidenced by a few case reports showing clinical improvement in some patients, with modest and self-resolving side effects. The natural history of these two syndromes remains poorly understood as only case-reports have been published. Therefore, an international consortium was created in December 2019 by Pr FAIVRE (CHU Dijon Bourgogne & ERN ITHACA) to follow treated and untreated patients in a real-life, multicentre, observational study, in order to expand our knowledge of these ultra-rare diseases. In the longer term, we believe that TKIs could bring clinical benefit to KOGS/PS patients.

NCT ID: NCT05547308 Not yet recruiting - Clinical trials for Congenital Abnormalities

Evaluation of 3D Printed Myoelectric Prosthetic Devices in Children With Upper Congenital Limb Deficiency

Start date: November 2022
Phase: N/A
Study type: Interventional

This will be a prospective study over a 14-month duration with clinical evaluations throughout. Limitless Solutions will provide prosthetics and training system for study subjects that qualify for enrollment.

NCT ID: NCT05328050 Recruiting - Achondroplasia Clinical Trials

Registry for Patients With Achondroplasia / Hypochondroplasia (OMPR-Ach/Hy)

OMPR-Ach/Hy
Start date: September 1, 2021
Phase:
Study type: Observational [Patient Registry]

This registry is a observational, single-center study designed to collect clinical data on patients with achondroplasia and hypochondroplasia.

NCT ID: NCT05182333 Not yet recruiting - Clinical trials for Congenital Limb Anomaly Nos

Congenital Hand and Upper Extremity Malformations

Start date: February 1, 2022
Phase:
Study type: Observational

Getting the incidence of upper limb anomalies in our department from 2000 to 2020 and classifying them using IFSSH classification and OMT classification

NCT ID: NCT04427007 Completed - Amputation Clinical Trials

Moisture Management Liner Effectiveness Study

Start date: July 1, 2020
Phase: N/A
Study type: Interventional

The comfort and fit of the residual limb within a prosthetic socket are of primary concern for many amputees. The residual limb is typically covered by non-breathable and non- thermally conductive materials that can create a warm and ultimately moist environment. The investigators have developed a silicone liner approach to remove sweat from the skin and out of the socket and to passively conduct heat from the skin using thermally conductive elastomers. This liner has been developed to work alongside a thermo-electric cooling (TEC)-based module called the Intrasocket Cooling Element (ICE) developed in a parallel project by Vivonics, Inc. and Liberating Technologies, Inc. The ICE device can be embedded into the prosthesis in order to cool the residual limb. A technology that can provide thermal control while retaining adequate suspension, weight, and other prosthetic characteristics would benefit many prosthesis wearers.

NCT ID: NCT04199975 Recruiting - Clinical trials for Upper Limb Deformities, Congenital

Customized Self-Controlled Power-Driven or Mechanical Orthoses for the Upper Limb - A Pilot Study

Start date: October 4, 2019
Phase: N/A
Study type: Interventional

Patients with congenital or acquired upper limb structural abnormalities and peripheral nerve or brachial plexus palsies have significant loss of function. The use of orthoses may improve function particularly in performing specific tasks for which the orthoses are designed, depending on the patients' deficiencies and needs. The performance of orthoses may be enhanced by being light-weight, motor-driven, and ergonomic. This pilot, prospective study is designed to test the feasibility and effectiveness of the specially designed orthoses.

NCT ID: NCT04059107 Enrolling by invitation - Clinical trials for Upper Limb Deformities, Congenital

Prosthetic Device in Children With Upper Congenital Limb Deficiency

Start date: July 3, 2019
Phase: N/A
Study type: Interventional

This is a study being performed to evaluate the safety and effectiveness of 3D printed myoelectric prosthetic devices in children with a congenital upper limb deficiency.