Retinal Imaging in Neurodegenerative Disease

Status Recruiting

Clinical Trial Summary

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

Clinical Trial Description

Using a multidisciplinary approach, this study aims to yield new insight into the vascular and structural pathophysiology of neurodegenerative disease. The investigators propose to develop and evaluate imaging biomarkers from OCT, OCTA, and UWF fundus photos to assess the structure and function of the retinal and choroidal microvasculature and structure in these individuals. The investigators hypothesize that microvascular and structural network alterations in the retina and choroid may mirror and possibly precede changes in the cerebral microcirculation seen in these neurodegenerative diseases. Using advanced image analysis and machine learning techniques, the investigators aim to evaluate markers of reduced capillary blood flow and non-perfusion in the superficial retinal vascular plexus and choriocapillaris imaged using OCT and OCTA, in a resolution not previously possible, that would complement already established retinal structural markers and increase their sensitivity and specificity in the earlier detection of these neurodegenerative diseases. This study looks to provide a proof of concept for retinal and choroidal imaging-based microvascular and structural biomarkers as an effective screening tool for neurodegenerative disease, particularly during in cognitive aging. The protocol for this study was amended and the record was updated accordingly. ;

Study Design

Related Conditions & MeSH terms

Alzheimer Disease
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS)
Aphasia, Primary Progressive
Brain Injuries
Brain Injuries, Traumatic
Cognitive Dysfunction
Concussion
Dementia
Down Syndrome
Frontotemporal Dementia
Huntington Disease
Lewy Body Dementia
Lewy Body Disease
Mild Cognitive Impairment
Motor Neuron Disease
Multiple Sclerosis
Neuro-Degenerative Disease
Neurodegenerative Diseases
Normal Cognition
Parkinson Disease
Parkinson's Disease
Pick Disease of the Brain
Post-Traumatic Stress Disorder
Sclerosis
Stress Disorders, Post-Traumatic
Stress Disorders, Traumatic
Traumatic Brain Injury

Clinical Trial Details

NCT number	NCT03233646
Study type	Observational
Source	Duke University
Contact	Sharon Fekrat, MD FACS FASRS
Phone	919-681-3937
Email	imind@duke.edu
Status	Recruiting
Phase
Start date	July 20, 2017
Completion date	December 31, 2025

View Details

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