Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

Updated 04/16/2024

Status Active, not recruiting

Clinical Trial Summary

This study is to find a safe dose of the combination of Avelumab and Whole Brain Radiotherapy (WBRT) in patients with Leptomeningeal Disease.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03719768
Study type	Interventional
Source	H. Lee Moffitt Cancer Center and Research Institute
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	June 10, 2019
Completion date	March 1, 2025

See also
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	Terminated	`NCT00005812` - Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma	Phase 2
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	Active, not recruiting	`NCT05289908` - Intrathecal Pemetrexed for Leptomeningeal Metastasis	Phase 1/Phase 2
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	Terminated	`NCT03275402` - 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases	Phase 2/Phase 3
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	Completed	`NCT03520504` - Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases	Phase 1
	Completed	`NCT00992602` - Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer	Phase 2
	Completed	`NCT00005811` - Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment	Phase 2
	Active, not recruiting	`NCT04343573` - Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors	Phase 2