Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

Updated 06/21/2024

Status Active, not recruiting

Clinical Trial Summary

This study is to find a safe dose of the combination of Avelumab and Whole Brain Radiotherapy (WBRT) in patients with Leptomeningeal Disease.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03719768
Study type	Interventional
Source	H. Lee Moffitt Cancer Center and Research Institute
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	June 10, 2019
Completion date	March 1, 2025

See also
	Status	Clinical Trial	Phase
	Withdrawn	`NCT01438021` - Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease	N/A
	Completed	`NCT02616393` - Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases	Phase 2
	Completed	`NCT03101579` - Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer	Phase 1
	Not yet recruiting	`NCT06462092` - Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer	Phase 1/Phase 2
	Terminated	`NCT00005812` - Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma	Phase 2
	Terminated	`NCT03661424` - BATs in Patients With Breast Cancer and Leptomeningeal Metastases	Phase 1
	Active, not recruiting	`NCT05289908` - Intrathecal Pemetrexed for Leptomeningeal Metastasis	Phase 1/Phase 2
	Recruiting	`NCT05184816` - A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis	Phase 1
	Not yet recruiting	`NCT03613181` - ANG1005 in Leptomeningeal Disease From Breast Cancer	Phase 3
	Terminated	`NCT03275402` - 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases	Phase 2/Phase 3
	Completed	`NCT01645839` - Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer	Phase 3
	Completed	`NCT03520504` - Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases	Phase 1
	Completed	`NCT00992602` - Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer	Phase 2
	Completed	`NCT00005811` - Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment	Phase 2
	Active, not recruiting	`NCT04343573` - Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors	Phase 2