Association Between Pseudoexfoliation Syndrome and Diabetes Mellitus

Lens Diseases Clinical Trial

Official title:

The Possible Association Between Pseudoexfoliation Syndrome and Diabetes Mellitus in an Egyptian Population

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03741153
• Other study ID #: PXSDM
• Status: Not yet recruiting
• Start date: January 2019
• Est. completion date: March 14, 2021

Study information

• Verified date: November 2018
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Pseudoexfoliation syndrome (PEX) is characterized by the deposition of a distinctive fibrillar material in the anterior segment of the eye and was first described in 1917 by Lindberg. It is frequently associated with open angle glaucoma, known as pseudoexfoliation glaucoma, which is one of the most common identifiable forms of secondary open angle glaucoma worldwide. Despite extensive research, the exactchemical nature of the fibrillar material is unknown. It is believed to be secreted multifocally in the iris pigment epithelium, the ciliary epithelium, and the peripheral anterior lens epithelium.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: March 14, 2021
• Est. primary completion date: December 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 50 Years and older

Eligibility

Inclusion Criteria:

• Phakic patients presenting to Ophthalmology outpatient clinic Of Assiut University Hospital.

Exclusion Criteria:

• Patients with previous intraocular surgery.

Related Conditions & MeSH terms

• Diabetes Mellitus
• Exfoliation Syndrome
• Lens Diseases

Intervention

Device:
• slit lamp
Presence of white grayish exfoliation material on the anterior lens capsule and / or the pupillary margin. Poor pupillary dilatation due to atrophy of the dilator pupillae muscle. The presence of pseudoexfoliative material (PXF)in cilliary processes and zonules. presence of PXF material scattered on corneal endothelium. Flecks of the exfoliative material on the anterior chamber which leads to glaucoma.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the percentage of diabetic patients with pseudo-exfoliation syndrome	slit lamp examination of all diabetic patients to get the percentage of those with pseudo-exfoliation syndrome	10 minutes