Leiomyosarcoma Clinical Trial
— CTCSOfficial title:
Detection of Circulating Tumor Cells in Patients With Metastatic Sarcomas
NCT number | NCT02983539 |
Other study ID # | ACFrance |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | October 2015 |
Est. completion date | June 2018 |
The sarcomas represent 1% of all cancers in adults, 8% in adolescents and young people, and
10% in children. Even though it is a rare cancer, it contributes to a significant loss of
years of life in comparison with other types of cancer, due the fact that it affects children
and young people. The diagnosis and treatment are difficult, considering the diversity and
rarity of this disease. In addition, on average, more than 50% of patients with high-grade
sarcoma present tumor relapse and distant recurrence is considered the main cause of death.
The presence of Circulating Tumor Cells (CTCs) in the blood of patients with sarcoma may be
an early marker of tumor invasion, because it is known that the CTCs circulate in the blood
for months or years before the development of metastases. The CTCs can be used to monitor the
response of the tumor to treatment, in order to match time, dose, and type of therapy.
Objectives: collect blood from patients with different types of sarcoma (leiomyosarcoma,
synovial sarcoma, pleomorphic sarcoma and liposarcoma) in order to isolate and quantify CTCs.
The investigators also have an intention to identify genes of resistance to treatment in
these cells.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | June 2018 |
Est. primary completion date | June 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: - 18 years or more; - types of sarcomas: leiomyosarcoma, pleomorphic sarcoma, synovial sarcoma and liposarcoma. - extension of the disease determined by physical examination and imaging; - measurable disease by RECIST criteria (Response Evaluation Criteria in Solid Tumors); Exclusion Criteria: - patients who have undergone previous therapy in the last three weeks; - patients with a history of other cancer in the past two years. |
Country | Name | City | State |
---|---|---|---|
Brazil | ACCamargo Cancer Center | Sao Paulo | SP |
Lead Sponsor | Collaborator |
---|---|
AC Camargo Cancer Center |
Brazil,
Abdallah EA, Fanelli MF, Souza E Silva V, Machado Netto MC, Gasparini Junior JL, Araújo DV, Ocea LM, Buim ME, Tariki MS, Alves Vda S, Piana de Andrade V, Dettino AL, Abdon Lopes de Mello C, Chinen LT. MRP1 expression in CTCs confers resistance to irinotecan-based chemotherapy in metastatic colorectal cancer. Int J Cancer. 2016 Aug 15;139(4):890-8. doi: 10.1002/ijc.30082. Epub 2016 Apr 28. — View Citation
Chinen LT, Mello CA, Abdallah EA, Ocea LM, Buim ME, Breve NM, Gasparini JL Junior, Fanelli MF, Paterlini-Bréchot P. Isolation, detection, and immunomorphological characterization of circulating tumor cells (CTCs) from patients with different types of sarc — View Citation
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---|---|---|---|---|
Primary | progression free survival | time to first progression until the second one | 6 months |
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