A Dose-escalating Clinical Trial With KH176

Status Completed

Clinical Trial Summary

Mitochondrial Diseases are rare progressive, multi-system, often early fatal disorders affecting both children and adults. KH176 is a novel chemical entity currently under development for the treatment of inherited mitochondrial diseases, including MELAS (Mitochondrial Encephalomyopathy, Lactic acidosis, and Stroke-like episodes), Leigh's Disease and Leber's Hereditary Optic Neuropathy (LHON). KH176 is a potent intracellular redox modulating agent targeting the reactive oxygen species which are important in the pathogenesis of disorders of mitochondrial oxidative phosphorylation. After demonstrating a favourable safety profile in the pre-clinical testing, the safety, tolerability and pharmacokinetic and pharmacodynamic characteristics of the compound will now be evaluated in healthy male subjects in this trial

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Leigh Disease
Leigh Syndrome
LHON
MELAS
Mitochondrial Disease
Mitochondrial Diseases
Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation

Clinical Trial Details

NCT number	NCT02544217
Study type	Interventional
Source	Khondrion BV
Contact
Status	Completed
Phase	Phase 1
Start date	May 2015
Completion date	October 2015

View Details

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