Wounds and Injuries Clinical Trial
Official title:
Wound Bacterial Microbiota and Their Antibiotic Resistance: a Prospective Cohort Study of Hospitalized Patients Originating From the Syrian Armed Conflict
The purpose of the study is to explore the microbiology in war-associated wounds of hospitalized patients from the Syrian armed conflict. Cultures collected from acute wounds with clinical signs of infection will be analyzed.
War-associated injuries often result in soft tissue and bone being contaminated with foreign
material, leading to infection (Fares et al. 2013; Covey, Lurate, and Hatton 2000). Wound
infections remain the greatest risk to life and restoration of function in war-wounded that
survive the first few hours (Tong 1972; Murray 2008).
The Syrian armed conflict broke out in 2011 and quickly deteriorated. Médecins Sans
Frontières/Doctors Without Borders (MSF) runs an emergency trauma project in the Ministry of
Health hospital in Ar Ramtha, Jordan, less than five kilometers from the Syrian border. At
this facility patients from the Syrian armed conflict receive treatment for blast- and
gunshot-injuries. Wounds are treated according to the International Committee of the Red
Cross war surgery protocol (Giannou and Baldan 2010). Wound management and healing has been
difficult and time consuming, often complicated by infections and antibiotic resistance.
Recommendations for treatment of war-associated infections are generally not supported by
cohort studies (Murray et al. 2008). High rates of war wound infections caused by
antimicrobial drug resistant organisms have been shown in the Middle East but reports
generally only include combatants. Due to the use of body armor and forward medical therapy
this data may not be applicable to a civilian setting. Furthermore, available studies are
either performed on old wounds (Teicher et al. 2014) or on all available culture samples,
disregarding infection signs (Sutter et al. 2011; Dau, Tloba, and Daw 2013). Without
clinical signs of infection, routine collection of peri-debridement culture samples is
inappropriate in war-associated injuries (Murray et al. 2008). The differentiation between
contamination and infecting organisms is crucial in order to avoid unnecessary medication,
especially limit the use of broad-spectrum antibiotics as overuse may lead to development of
multi-drug resistant organisms (Eardley et al. 2011). Cultures collected from acute wounds
with clinical signs of infection will be analyzed.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04554212 -
Blood Flow Restriction Training After Patellar INStability
|
N/A | |
Suspended |
NCT02932176 -
Machine Learning for Handheld Vascular Studies
|
||
Recruiting |
NCT04803253 -
Study of the Social and Professional Reintegration Improvements Using a Set of Solutions for Upper Limb Amputation
|
N/A | |
Completed |
NCT00116337 -
Spinal Cord Stimulation to Restore Cough
|
N/A | |
Completed |
NCT03463720 -
Outcome for Patients With War-Associated Extremity Wound Infection
|
N/A | |
Completed |
NCT03113253 -
TRANexamic Acid to Reduce Bleeding in BURN Surgery
|
Phase 4 | |
Not yet recruiting |
NCT05492903 -
COMmunity of Practice And Safety Support for Navigating Pain (COMPASS-NP)
|
N/A | |
Terminated |
NCT02909231 -
One-year Patient Reported Outcomes Following Hospitalization for Trauma
|
N/A | |
Completed |
NCT02432456 -
Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients
|
Phase 4 | |
Completed |
NCT02266771 -
Impact of V.A.C. Veraflo Therapy in Wounds Requiring Debridement Within an Orthopedic Practice
|
N/A | |
Completed |
NCT02394821 -
Odor Management in Fungating Wounds Comparing Metronidazole and Polihexanide
|
Phase 3 | |
Not yet recruiting |
NCT01665963 -
Efficacy of TopClosure(C)System in Healing Complicated Pacemaker Wounds
|
N/A | |
Completed |
NCT00151112 -
Comparison of Two Different Procedures for Plexus Anesthesia
|
N/A | |
Not yet recruiting |
NCT03872544 -
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
Recruiting |
NCT04596124 -
Effectiveness and Tolerability of Fitostimoline Plus Cream and Gauze vs Connettivina Bio Plus Cream and Gauze
|
N/A | |
Recruiting |
NCT05800834 -
Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds
|
Phase 2 | |
Enrolling by invitation |
NCT03880188 -
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
Terminated |
NCT04775316 -
Prospective, International, Multicenter, Observational Study to Evaluate the Clinical Performance and Safety of a Silicone-coated Transparent Postoperative Dressing
|
||
Enrolling by invitation |
NCT03312504 -
Implementing a School Prevention Program to Reduce Injuries Through Neuromuscular Training
|
N/A | |
Terminated |
NCT03688880 -
A Clinical Study to Compare MAR-CUTIS With Dermabond Advanced
|
N/A |