Heart Failure, Systolic Clinical Trial
Official title:
Reprogramming to Prevent Progressive Pacemaker-Induced Remodelling
The aim is to provide evidence of the long-term benefits of personalised pacemaker
programming on heart function and battery longevity.
This will be achieved by showing in a single centre, phase II, double-blind, randomised,
placebo-controlled trial that reducing the amount of pacemaker beats to a minimum reverses
these changes and extends battery life.
Patients (n=70) with long-term (>2 years) permanent pacemakers with avoidable RV pacing will be invited to participate in a single-centre, phase II, randomised, double-blind placebo-controlled trial of optimised pacing programming versus standard care. Those randomised to the intervention arm will have personalised programming to avoid right ventricular pacing, whilst those allocated to standard care will have no programming changes made. All participants will be invited back at 6 months for a repeat echocardiogram, quality of life assessment (EQ-5D-5L), blood tests and pacemaker check. ;
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