Left Ventricular Hypertrophy Clinical Trial
Official title:
Value of Different Myocardial Parameters to Differentiate Left Ventricular Noncompaction Cardiomyopathy From Other Cardiomyopathies and Healthy Controls by Cardiac Magnetic Resonance
Left ventricular non-compaction (LVNC) is a rare cardiomyopathy characterized by numerous
excessively prominent left ventricular (LV) trabeculation and deep intertrabecular recesses
communicating with the ventricular cavity and severely altering myocardial structure.
Although most authors assume a developmental arrest in embryogenesis as the underlying
pathology, the mechanisms of LVNC are not fully understood yet. Several gene mutations have
been identified to be linked with LVNC and an autosomal dominant inheritance pattern is
frequent To date the most commonly used imaging tool for diagnosing LVNC is echocardiography
applying the criteria established by Jenni and coauthors However, qualitative parameters to
differentiate normal compaction of the myocardium in healthy subjects from LVNC or from
other cardiomyopathies like dilative cardiomyopathy (DCM) or hypertrophic cardiomyopathy
(HCM) may fail due to highly variable LV trabeculation. Therefore, absolute quantification
should be performed. Cardiac magnetic resonance (CMR) has been reported as a promising
imaging modality to characterize patients with LVNC as it provides both a high spatial
resolution and a good contrast between trabeculation and blood pool Jacquier et al. recently
described a value of trabeculated LV myocardial mass above 20% of the global mass of the LV
to be highly sensitive and specific for LVNC However, in their approach, a substantial
degree of the LV cavity was included into calculated trabecular LV mass and led to systemic
overestimation of the latter. Furthermore, the role and prognostic value of myocardial
scarring as assessed by delayed enhancement (DE) CMR was not evaluated.
The aim of the retrospective study was to establish revised and extended CMR criteria to
distinguish LVNC from DCM, HCM and a group of healthy controls and to improve the assessment
of trabeculated mass by excluding intertrabecular blood pool.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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